S100A8 抗体
Quick Overview for S100A8 抗体 (ABIN7605595)
抗原
See all S100A8 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- Anti-MRP8 S100A8 Rabbit Monoclonal Antibody
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产品特性
- Anti-MRP8 A8 Rabbit Monoclonal Antibody (ABIN7605595). Tested in WB, IHC, IP applications. This antibody reacts with Human, Mouse.
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纯化方法
- Affinity-chromatography
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免疫原
- A synthesized peptide derived from human MRP8
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亚型
- IgG
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应用备注
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WB 1:500-1:2000
IHC 1:50-1:200
IP 1:30 -
限制
- 仅限研究用
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状态
- Liquid
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溶解方式
- Restore with deionized water (or equivalent) for reconstitution volume of 1.0 mL
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浓度
- Lot specific
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缓冲液
- Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol, 0.4-0.5 mg/mL BSA.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
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- S100A8 (S100 Calcium Binding Protein A8 (S100A8))
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别名
- S100A8
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背景
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Synonyms: Protein S100-A8,Calgranulin-A,Calprotectin L1L subunit,Cystic fibrosis antigen,CFAG,Leukocyte L1 complex light chain,Migration inhibitory factor-related protein 8,MRP-8,p8,S100 calcium-binding protein A8,Urinary stone protein band A,Protein S100-A8, N-terminally processed,S100A8,CAGA, CFAG, MRP8,
Tissue Specificity: Calprotectin (S100A8/9) is predominantly expressed in myeloid cells. Except for inflammatory conditions, the expression is restricted to a specific stage of myeloid differentiation since both proteins are expressed in circulating neutrophils and monocytes but are absent in normal tissue macrophages and lymphocytes. Under chronic inflammatory conditions, such as psoriasis and malignant disorders, also expressed in the epidermis. Found in high concentrations at local sites of inflammation or in the serum of patients with inflammatory diseases such as rheumatoid, cystic fibrosis, inflammatory bowel disease, Crohn's disease, giant cell arteritis, cystic fibrosis, Sjogren's syndrome, systemic lupus erythematosus, and progressive systemic sclerosis. Involved in the formation and deposition of amyloids in the aging prostate known as corpora amylacea inclusions. Strongly up-regulated in many tumors, including gastric, esophageal, colon, pancreatic, bladder, ovarian, thyroid, breast and skin cancers. .
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分子量
- 52 kDa
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UniProt
- P05109
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途径
- Transition Metal Ion Homeostasis, Positive Regulation of Endopeptidase Activity, S100 Proteins
抗原
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