Insulin Receptor 抗体
Quick Overview for Insulin Receptor 抗体 (ABIN7605279)
抗原
See all Insulin Receptor (INSR) 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- Anti-Insulin Receptor INSR Rabbit Monoclonal Antibody
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产品特性
- Anti-Insulin Receptor INSR Rabbit Monoclonal Antibody (ABIN7605279). Tested in WB, ICC/IF applications. This antibody reacts with Human, Rat.
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纯化方法
- Affinity-chromatography
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免疫原
- A synthesized peptide derived from human Insulin Receptor
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亚型
- IgG
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应用备注
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WB 1:1000-1:2000
ICC/IF 1:50-1:200 -
限制
- 仅限研究用
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状态
- Liquid
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溶解方式
- Restore with deionized water (or equivalent) for reconstitution volume of 1.0 mL
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浓度
- Lot specific
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缓冲液
- Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol, 0.4-0.5 mg/mL BSA.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
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- Insulin Receptor (INSR)
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别名
- INSR
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背景
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Synonyms: Insulin receptor,IR,2.7.10.1,CD220,Insulin receptor subunit alpha,Insulin receptor subunit beta,INSR,
Tissue Specificity: Isoform Long and isoform Short are predominantly expressed in tissue targets of insulin metabolic effects: liver, adipose tissue and skeletal muscle but are also expressed in the peripheral nerve, kidney, pulmonary alveoli, pancreatic acini, placenta vascular endothelium, fibroblasts, monocytes, granulocytes, erythrocytes and skin. Isoform Short is preferentially expressed in fetal cells such as fetal fibroblasts, muscle, liver and kidney. Found as a hybrid receptor with IGF1R in muscle, heart, kidney, adipose tissue, skeletal muscle, hepatoma, fibroblasts, spleen and placenta (at protein level). Overexpressed in several tumors, including breast, colon, lung, ovary, and thyroid carcinomas. .
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分子量
- 73 kDa
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UniProt
- P06213
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途径
- NF-kappaB Signaling, RTK signaling, AMPK Signaling, Carbohydrate Homeostasis, Regulation of Cell Size, Regulation of Carbohydrate Metabolic Process, Growth Factor Binding, Negative Regulation of Transporter Activity
抗原
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