HNF4A 抗体
Quick Overview for HNF4A 抗体 (ABIN7605142)
抗原
See all HNF4A 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- Anti-HNF-4-alpha Rabbit Monoclonal Antibody
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产品特性
- Anti-HNF-4-alpha Rabbit Monoclonal Antibody (ABIN7605142). Tested in WB, IHC, ICC/IF, Flow Cytometry applications. This antibody reacts with Human.
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纯化方法
- Affinity-chromatography
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免疫原
- A synthesized peptide derived from human HNF-4-alpha
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亚型
- IgG
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应用备注
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WB 1:500-1:2000
IHC 1:50-1:200
ICC/IF 1:50-1:200
FC 1:50 -
限制
- 仅限研究用
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状态
- Liquid
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溶解方式
- Restore with deionized water (or equivalent) for reconstitution volume of 1.0 mL
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浓度
- Lot specific
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缓冲液
- Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol, 0.4-0.5 mg/mL BSA.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
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- HNF4A (Hepatocyte Nuclear Factor 4, alpha (HNF4A))
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别名
- HNF4A
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背景
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Synonyms: Hepatocyte nuclear factor 4-alpha,HNF-4-alpha,Nuclear receptor subfamily 2 group A member 1,Transcription factor 14,TCF-14,Transcription factor HNF-4,HNF4A,HNF4, NR2A1, TCF14,
Tissue Specificity: Calprotectin (S100A8/9) is predominantly expressed in myeloid cells. Except for inflammatory conditions, the expression is restricted to a specific stage of myeloid differentiation since both proteins are expressed in circulating neutrophils and monocytes but are absent in normal tissue macrophages and lymphocytes. Under chronic inflammatory conditions, such as psoriasis and malignant disorders, also expressed in the epidermis. Found in high concentrations at local sites of inflammation or in the serum of patients with inflammatory diseases such as rheumatoid, cystic fibrosis, inflammatory bowel disease, Crohn's disease, giant cell arteritis, cystic fibrosis, Sjogren's syndrome, systemic lupus erythematosus, and progressive systemic sclerosis. Involved in the formation and deposition of amyloids in the aging prostate known as corpora amylacea inclusions. Strongly up-regulated in many tumors, including gastric, esophageal, colon, pancreatic, bladder, ovarian, thyroid, breast and skin cancers. .
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分子量
- 125 kDa
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UniProt
- P41235
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途径
- AMPK Signaling, Nuclear Receptor Transcription Pathway, Steroid Hormone Mediated Signaling Pathway, Carbohydrate Homeostasis, Cell-Cell Junction Organization, Regulation of Carbohydrate Metabolic Process
抗原
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