SMC1A 抗体 (pSer957)
Quick Overview for SMC1A 抗体 (pSer957) (ABIN7603375)
抗原
See all SMC1A 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
-
-
抗原表位
- pSer957
-
原理
- Anti-Phospho-SMC1 (S957) Monoclonal Antibody
-
产品特性
- Anti-Phospho-SMC1 Monoclonal Antibody (ABIN7603375). Tested in WB, IHC, ICC/IF applications. This antibody reacts with Human.
-
纯化方法
- Affinity-chromatography
-
免疫原
- A synthesized peptide derived from human Phospho-SMC1 (S957) Structural maintenance of chromosomes 1 (SMC1) protein is a chromosomal protein member of the cohesin complex that enables sister chromatid cohesion and plays a role in DNA repair . ATM/NBS1-dependent phosphorylation of SMC1 occurs at Ser957 and Ser966 in response to ionizing radiation (IR) as part of the intra-S-phase DNA damage checkpoint. SMC1 phosphorylation is ATM-independent in cells subjected to other forms of DNA damage, including UV light and hydroxyurea treatment.
-
亚型
- IgG
-
-
-
-
应用备注
-
WB 1:500-1:2000
IHC 1:50-1:200
ICC/IF 1:50-1:200 -
限制
- 仅限研究用
-
-
-
状态
- Liquid
-
浓度
- Lot specific
-
缓冲液
- Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol, 0.4-0.5 mg/mL BSA.
-
储存液
- Sodium azide
-
注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
储存条件
- 4 °C,-20 °C
-
储存方法
- Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
-
-
- SMC1A (Structural Maintenance of Chromosomes 1A (SMC1A))
-
别名
- SMC1A
-
背景
-
Synonyms: Red fluorescent protein eqFP611,GFP-like chromoprotein,
Tissue Specificity: Highly and selectively expressed by undifferentiated rather than differentiated embryonic stem cells (ESC). Levels rapidly diminish as soon as ESC's differentiate (at protein levels). Expressed in almost all epithelial cell membranes but not on mesodermal or neural cell membranes. Found on the surface of adenocarcinoma. .
-
分子量
- 15 kDa
-
UniProt
- Q14683
-
途径
- Stem Cell Maintenance
抗原
-