GRK2 抗体 (C-Term)
Quick Overview for GRK2 抗体 (C-Term) (ABIN7602826)
抗原
See all GRK2 (ADRBK1) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- C-Term
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原理
- Anti-GRK2 Antibody Picoband®
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交叉反应 （详细）
- No cross-reactivity with other proteins.
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产品特性
- Anti-GRK2 Antibody Picoband® (ABIN7602826). Tested in Flow Cytometry, IF, ICC, WB applications. This antibody reacts with Human, Monkey, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
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纯化方法
- Immunogen affinity purified.
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免疫原
- A synthetic peptide corresponding to a sequence at the C-terminus of human GRK2, identical to the related mouse and rat sequences.
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亚型
- IgG
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anti-Adrenergic, Beta, Receptor Kinase 1 (ADRBK1) (AA 440-689) antibody
ADRBK1 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Adrenergic, Beta, Receptor Kinase 1 (ADRBK1) (C-Term) antibodyKO Validated ADRBK1 适用: 人 WB, IHC (p), IF, ICC, FACS, IP 宿主: 兔 Polyclonal unconjugated
anti-Adrenergic, Beta, Receptor Kinase 1 (ADRBK1) antibodyADRBK1 适用: 人, 小鼠, 大鼠, 猴 WB, ELISA, IHC, ICC 宿主: 小鼠 Monoclonal 3F8 unconjugated
anti-Adrenergic, Beta, Receptor Kinase 1 (ADRBK1) (Internal Region) antibodyADRBK1 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Adrenergic, Beta, Receptor Kinase 1 (ADRBK1) (AA 633-660), (C-Term) antibodyADRBK1 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB0982 unconjugated
anti-Adrenergic, Beta, Receptor Kinase 1 (ADRBK1) (C-Term) antibodyADRBK1 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Adrenergic, Beta, Receptor Kinase 1 (ADRBK1) (N-Term) antibodyADRBK1 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Adrenergic, Beta, Receptor Kinase 1 (ADRBK1) (AA 2-221) antibodyADRBK1 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Adrenergic, Beta, Receptor Kinase 1 (ADRBK1) (Internal Region) antibodyVerified ADRBK1 适用: 人 WB, ELISA 宿主: 山羊 Polyclonal unconjugated
anti-Adrenergic, Beta, Receptor Kinase 1 (ADRBK1) (C-Term) antibodyADRBK1 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
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应用备注
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Western blot, 0.25-0.5 μg/mL, Human, Mouse, Rat, Monkey
Immunocytochemistry/Immunofluorescence, 5 μg/mL, Human
Flow Cytometry (Fixed), 1-3 μg/1x106 cells, Human, Mouse, Rat
1. Benovic JL, DeBlasi A, Stone WC, Caron MG, Lefkowitz RJ (1989). "Beta-adrenergic receptor kinase: primary structure delineates a multigene family". Science. 246 (4927): 235-40. 2. Pippig S, Andexinger S, Daniel K, Puzicha M, Caron MG, Lefkowitz RJ, Lohse MJ (1993). "Overexpression of beta-arrestin and beta-adrenergic receptor kinase augment desensitization of beta 2-adrenergic receptors".J. Biol. Chem. 268 (5): 3201-8. -
限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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浓度
- 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.01 mg Sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
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Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
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- GRK2 (ADRBK1) (Adrenergic, Beta, Receptor Kinase 1 (ADRBK1))
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别名
- GRK2
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背景
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Synonyms: Protein Bop, BH3-only protein, Retrotransposon Gag-like protein 10, RTL10, BOP, C22orf29
Tissue Specificity: Ubiquitously expressed.
Background: Beta adrenergic receptor kinase (also referred to as βARK or BARK) is a serine/threonine intracellular kinase. The product of this gene phosphorylates the beta-2-adrenergic receptor and appears to mediate agonist-specific desensitization observed at high agonist concentrations. This protein is an ubiquitous cytosolic enzyme that specifically phosphorylates the activated form of the beta-adrenergic and related G-protein-coupled receptors. Abnormal coupling of beta-adrenergic receptor to G protein is involved in the pathogenesis of the failing heart.
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分子量
- 80 kDa
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基因ID
- 156
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UniProt
- P25098
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途径
- EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Regulation of G-Protein Coupled Receptor Protein Signaling, CXCR4-mediated Signaling Events, G-protein mediated Events, Interaction of EGFR with phospholipase C-gamma, Thromboxane A2 Receptor Signaling
抗原
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