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GRK2 抗体 (C-Term)

There are 6+ publications for this product available. The 兔多克隆 anti-GRK2 antibody is suitable to detect GRK2 in samples from 人. It has been validated for WB 和 IHC (p).

Formalin-fixed and paraffin-embedded human lung carcinoma tissue reacted with GRK2 Antibody (C-term) (ABIN1882061 and ABIN2841168) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. (GRK2 抗体 (C-Term))

IHC (p)

Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. (GRK2 抗体 (C-Term))

IHC (p)

3 images

(6 references)

产品编号 ABIN1882061

发货至: 中国

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Quick Overview for GRK2 抗体 (C-Term) (ABIN1882061)

抗原

See all GRK2 (ADRBK1) 抗体

GRK2 (ADRBK1) (Adrenergic, Beta, Receptor Kinase 1 (ADRBK1))

适用

人

宿主

兔

克隆类型

多克隆

标记

This GRK2 antibody is un-conjugated

应用范围

Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

克隆位点

RB0982

Discover our top product ADRBK1 Primary Antibody

抗原表位
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1

1

1

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1

1
AA 633-660, C-Term

预测反应

B, M, Rat

纯化方法

This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

免疫原

This ADRBK1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 633-660 amino acids from the C-terminal region of human ADRBK1.

亚型

Ig Fraction
anti-Adrenergic, Beta, Receptor Kinase 1 (ADRBK1) (AA 398-640) antibody
ADRBK1 适用: 人 WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated

anti-Adrenergic, Beta, Receptor Kinase 1 (ADRBK1) (AA 440-689) antibody
ADRBK1 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated

anti-Adrenergic, Beta, Receptor Kinase 1 (ADRBK1) (C-Term) antibody
KO Validated ADRBK1 适用: 人 WB, IHC (p), IF, ICC, IP, FACS 宿主: 兔 Polyclonal unconjugated

anti-Adrenergic, Beta, Receptor Kinase 1 (ADRBK1) antibody
ADRBK1 适用: 人, 小鼠, 大鼠, 猴 WB, ELISA, IHC, ICC 宿主: 小鼠 Monoclonal 3F8 unconjugated

anti-Adrenergic, Beta, Receptor Kinase 1 (ADRBK1) (Internal Region) antibody
ADRBK1 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated

anti-Adrenergic, Beta, Receptor Kinase 1 (ADRBK1) (C-Term) antibody
ADRBK1 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated

anti-Adrenergic, Beta, Receptor Kinase 1 (ADRBK1) (N-Term) antibody
ADRBK1 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated

anti-Adrenergic, Beta, Receptor Kinase 1 (ADRBK1) (AA 2-221) antibody
ADRBK1 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated

anti-Adrenergic, Beta, Receptor Kinase 1 (ADRBK1) (C-Term) antibody
ADRBK1 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated

anti-Adrenergic, Beta, Receptor Kinase 1 (ADRBK1) (C-Term) antibody
ADRBK1 适用: 人 WB, ELISA, IHC, FM 宿主: 山羊 Polyclonal unconjugated

应用备注

WB: 1:1000. IHC-P: 1:50~100. IHC-P: 1:50~100

限制

仅限研究用
状态

Liquid

缓冲液

Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

4 °C,-20 °C

有效期

6 months
Rao, Rapoport, Kim: "Decreased GRK3 but not GRK2 expression in frontal cortex from bipolar disorder patients." in: The international journal of neuropsychopharmacology / official scientific journal of the Collegium Internationale Neuropsychopharmacologicum (CINP), Vol. 12, Issue 6, pp. 851-60, (2009) (PubMed).

Eichmann, Lorenz, Hoffmann, Brockmann, Krasel, Lohse, Quitterer: "The amino-terminal domain of G-protein-coupled receptor kinase 2 is a regulatory Gbeta gamma binding site." in: The Journal of biological chemistry, Vol. 278, Issue 10, pp. 8052-7, (2003) (PubMed).

Li, Xiang, Su, Zhang, Huang, Ma: "Agonist-induced formation of opioid receptor-G protein-coupled receptor kinase (GRK)-G beta gamma complex on membrane is required for GRK2 function in vivo." in: The Journal of biological chemistry, Vol. 278, Issue 32, pp. 30219-26, (2003) (PubMed).

Wan, Sambi, Tate, Waters, Pyne et al.: "The inhibitory gamma subunit of the type 6 retinal cGMP phosphodiesterase functions to link c-Src and G-protein-coupled receptor kinase 2 in a signaling unit that regulates p42/p44 mitogen-activated ..." in: The Journal of biological chemistry, Vol. 278, Issue 20, pp. 18658-63, (2003) (PubMed).

Yang, Zhang, Lai, Xing, Liu: "Pleckstrin homology domain of G protein-coupled receptor kinase-2 binds to PKC and affects the activity of PKC kinase." in: World journal of gastroenterology : WJG, Vol. 9, Issue 4, pp. 800-3, (2003) (PubMed).

Hagen, Kondyra, Grocott, El-Moalem, Bainbridge, Mathew, Newman, Reves, Schwinn, Kwatra: "Cardiopulmonary bypass decreases G protein-coupled receptor kinase activity and expression in human peripheral blood mononuclear cells." in: Anesthesiology, Vol. 98, Issue 2, pp. 343-8, (2003) (PubMed).
抗原

GRK2 (ADRBK1) (Adrenergic, Beta, Receptor Kinase 1 (ADRBK1))

别名

ADRBK1

背景

Beta-adrenergic receptor kinase (ADRBK1), also known as GRK2, phosphorylates the beta-2-adrenergic receptor and appears to mediate agonist-specific desensitization observed at high agonist concentrations. ADRBK1 is an ubiquitous cytosolic enzyme that specifically phosphorylates the activated form of the beta-adrenergic and related G-protein-coupled receptors. Heart failure is accompanied by severely impaired beta-adrenergic receptor (beta-AR) function. An important mechanism for the rapid desensitization of beta-AR function is agonist-stimulated receptor phosphorylation by the beta-AR kinase (beta-ARK1), an enzyme known to be elevated in failing human heart tissue. Abnormal coupling of beta-adrenergic receptor to G protein is involved in the pathogenesis of the failing heart.

分子量

79574

NCBI登录号

NP_001610

UniProt

P25098

途径

EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Regulation of G-Protein Coupled Receptor Protein Signaling, CXCR4-mediated Signaling Events, G-protein mediated Events, Interaction of EGFR with phospholipase C-gamma, Thromboxane A2 Receptor Signaling