Plakophilin 2 抗体 (AA 9-866)
Quick Overview for Plakophilin 2 抗体 (AA 9-866) (ABIN7602642)
抗原
See all Plakophilin 2 (PKP2) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 9-866
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原理
- Anti-Plakophilin 2/PKP2 Antibody Picoband®
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交叉反应 （详细）
- No cross-reactivity with other proteins.
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产品特性
- Anti-Plakophilin 2/PKP2 Antibody Picoband® (ABIN7602642). Tested in ELISA, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
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纯化方法
- Immunogen affinity purified.
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免疫原
- E.coli-derived mouse Plakophilin 2/PKP2 recombinant protein (Position: E9-D866).
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亚型
- IgG
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anti-Plakophilin 2 (PKP2) (AA 801-881) antibody
PKP2 适用: 人 ELISA, IHC (p), ICC, IHC (fro), IF (cc), IF (p) 宿主: 兔 Polyclonal unconjugated
anti-Plakophilin 2 (PKP2) (N-Term) antibodyPKP2 适用: 人, 大鼠, 小鼠, 犬, Cow, 马 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Plakophilin 2 (PKP2) (C-Term) antibodyPKP2 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Plakophilin 2 (PKP2) (AA 61-183) antibodyPKP2 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Plakophilin 2 (PKP2) (AA 125-139) antibodyVerified PKP2 适用: 人, 小鼠 WB, ELISA, IHC 宿主: 山羊 Polyclonal unconjugated
anti-Plakophilin 2 (PKP2) (C-Term) antibodyPKP2 适用: 人, 大鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Plakophilin 2 (PKP2) (AA 1-350) antibodyPKP2 适用: 人, 小鼠 WB, IP, IHC (p), FACS 宿主: 小鼠 Monoclonal 8H6 unconjugated
anti-Plakophilin 2 (PKP2) (N-Term) antibodyPKP2 适用: 人, 大鼠 WB, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Plakophilin 2 (PKP2) (AA 571-849) antibodyPKP2 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Plakophilin 2 (PKP2) antibodyPKP2 适用: 人, 大鼠, 小鼠 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
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应用备注
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Western blot, 0.25-0.5 μg/mL, Human, Mouse, Rat
ELISA, 0.1-0.5 μg/mL, -
1. Bonne, S., van Hengel, J., van Roy, F. Chromosomal mapping of human armadillo genes belonging to the p120(ctn)/plakophilin subfamily. Genomics 51: 452-454, 1998 2. Bonne, S., van Hengel, J, van Roy, F. Assignment of the plakophilin-2 gene (PKP2) and a plakophilin-2 pseudogene (PKP2P1) to human chromosome bands 12p11 and 12p13, respectively, by in situ hybridization. Cytogenet. Cell Genet. 88: 286-287, 2000. 3. Dalal, D., Molin, L. H., Piccini, J., Tichnell, C., James, C., Bomma, C., Prakasa, K., Towbin, J. A., Marcus, F. I., Spevak, P. J., Bluemke, D. A., Abraham, T., Russell, S. D., Calkins, H., Judge, D. P. Clinical features of arrhythmogenic right ventricular dysplasia/cardiomyopathy associated with mutations in plakophilin-2. Circulation 113: 1641-1649, 2006. -
限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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浓度
- 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
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At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.
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- Plakophilin 2 (PKP2)
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别名
- PKP2
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背景
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Synonyms: Mucin-6, MUC-6, Gastric mucin-6, MUC6
Tissue Specificity: Expressed in the regenerative zone of gastric antrum, gastric body mucosa and gastric incisura mucosa. Expressed in the deeper mucous glands of gastric antrum. Overexpressed in Helicobacter pylori infected gastric epithelium. Highly expressed in duodenal Brunner's glands, gall bladder, seminal vesicle, pancreatic centroacinar cells and ducts, and periductal glands of the common bile duct.
Background: Plakophilin-2 is a protein that in humans is encoded by the PKP2 gene. This gene encodes a member of the arm-repeat (armadillo) and plakophilin gene families. Plakophilin proteins contain numerous armadillo repeats, localize to cell desmosomes and nuclei, and participate in linking cadherins to intermediate filaments in the cytoskeleton. This gene may regulate the signaling activity of beta-catenin and is required to maintain transcription of genes that control intracellular calcium cycling including ryanodine receptor 2, ankyrin-B, triadin, and calcium channel, voltage-dependent, L type, alpha 1C. Mutations in this gene are associated with different inherited cardiac conditions including Arrythmogenic Cardiomyopathy, Brugada Syndrome, and Idiopathic Ventricular Fibrillation. A processed pseudogene with high similarity to this gene has been mapped to chromosome 12p13.
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分子量
- 92 kDa
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基因ID
- 5318
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UniProt
- Q99959
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途径
- Cell-Cell Junction Organization, SARS-CoV-2 Protein Interactome, The Global Phosphorylation Landscape of SARS-CoV-2 Infection
抗原
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