SHP1 抗体 (AA 67-572)
Quick Overview for SHP1 抗体 (AA 67-572) (ABIN7602271)
抗原
See all SHP1 (PTPN6) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 67-572
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原理
- Anti-SHP1/PTPN6 Antibody Picoband®
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交叉反应 （详细）
- No cross-reactivity with other proteins.
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产品特性
- Anti-SHP1/PTPN6 Antibody Picoband® (ABIN7602271). Tested in ELISA, Flow Cytometry, IF, ICC, WB applications. This antibody reacts with Human, Mouse. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
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纯化方法
- Immunogen affinity purified.
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免疫原
- E.coli-derived human SHP1/PTPN6 recombinant protein (Position: E67-K572).
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亚型
- IgG
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anti-Protein-tyrosine Phosphatase 1C (PTPN6) antibody
PTPN6 适用: 人 WB, IHC, IF, FACS, StM 宿主: 小鼠 Monoclonal CPTC-APEX1-2 unconjugated
anti-Protein-tyrosine Phosphatase 1C (PTPN6) antibodyPTPN6 适用: 人 WB, IHC (p), IP, IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Protein-tyrosine Phosphatase 1C (PTPN6) (AA 1-595) antibodyPTPN6 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Protein-tyrosine Phosphatase 1C (PTPN6) (AA 243-541) antibodyPTPN6 适用: 人 ELISA, FACS, ICC 宿主: 小鼠 Monoclonal 2E9E4 unconjugated
anti-Protein-tyrosine Phosphatase 1C (PTPN6) (AA 1-597), (Isoform 2) antibodyPTPN6 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Protein-tyrosine Phosphatase 1C (PTPN6) (C-Term) antibodyPTPN6 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Protein-tyrosine Phosphatase 1C (PTPN6) (pTyr536) antibodyPTPN6 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Protein-tyrosine Phosphatase 1C (PTPN6) (AA 100-400) antibodyPTPN6 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Protein-tyrosine Phosphatase 1C (PTPN6) (AA 247-277) antibodyPTPN6 适用: 人 WB, IF, IHC (p) 宿主: 兔 Polyclonal RB17225 unconjugated
anti-Protein-tyrosine Phosphatase 1C (PTPN6) antibodyPTPN6 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
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应用备注
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Western blot, 0.25-0.5 μg/mL, Human, Mouse
Immunocytochemistry/Immunofluorescence, 5 μg/mL, Human
Flow Cytometry (Fixed), 1-3 μg/1x106 cells, Human
ELISA, 0.1-0.5 μg/mL, -
1. Banville, D., Stocco, R., Shen, S.-H. Human protein tyrosine phosphatase 1C (PTPN6) gene structure: alternate promoter usage and exon skipping generate multiple transcripts. Genomics 27: 165-173, 1995. 2. Beghini, A., Ripamonti, C. B., Peterlongo, P., Roversi, G., Cairoli, R., Morra, E., Larizza, L. RNA hyperediting and alternative splicing of hematopoietic cell phosphatase (PTPN6) gene in acute myeloid leukemia. Hum. Molec. Genet. 9: 2297-2304, 2000. 3. Croker, B. A., Lawson, B. R., Rutschmann, S., Berger, M., Eidenschenk, C., Blasius, A. L., Moresco, E. M. Y., Sovath, S., Cengia, L., Shultz, L. D., Theofilopoulos, A. N., Pettersson, S., Beutler, B. A. Inflammation and autoimmunity caused by a SHP1 mutation depend on IL-1, MyD88, and microbial trigger. Proc. Nat. Acad. Sci. 105: 15028-15033, 2008. Note: Erratum: Proc. Nat. Acad. Sci. 105: 19561 only, 2008. -
限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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浓度
- 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.01 mg Sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
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Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
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- SHP1 (PTPN6) (Protein-tyrosine Phosphatase 1C (PTPN6))
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别名
- PTPN6
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背景
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Synonyms: Tafazzin, Protein G4.5, TAZ, EFE2, G4.5
Tissue Specificity: High levels in cardiac and skeletal muscle. Up to 10 isoforms can be present in different amounts in different tissues. Most isoforms are ubiquitous. Isoforms that lack the N-terminus are found in leukocytes and fibroblasts, but not in heart and skeletal muscle. Some forms appear restricted to cardiac and skeletal muscle or to leukocytes.
Background: Tyrosine-protein phosphatase non-receptor type 6, also known as Src homology region 2 domain-containing phosphatase-1 (SHP-1), is an enzyme that in humans is encoded by the PTPN6 gene. The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. N-terminal part of this PTP contains two tandem Src homolog (SH2) domains, which act as protein phospho-tyrosine binding domains, and mediate the interaction of this PTP with its substrates. This PTP is expressed primarily in hematopoietic cells, and functions as an important regulator of multiple signaling pathways in hematopoietic cells. This PTP has been shown to interact with, and dephosphorylate a wide spectrum of phospho-proteins involved in hematopoietic cell signaling. Multiple alternatively spliced variants of this gene, which encode distinct isoforms, have been reported.
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分子量
- 68 kDa
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基因ID
- 5777
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UniProt
- P29350
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途径
- JAK/STAT Signaling, TCR Signaling, TLR signaling, Nuclear Receptor Transcription Pathway, Positive Regulation of Peptide Hormone Secretion, Steroid Hormone Mediated Signaling Pathway, Response to Growth Hormone Stimulus, Regulation of Leukocyte Mediated Immunity, CXCR4-mediated Signaling Events, Signaling Events mediated by VEGFR1 and VEGFR2, BCR Signaling
抗原
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