PTRF 抗体 (AA 47-390)
Quick Overview for PTRF 抗体 (AA 47-390) (ABIN7601817)
抗原
See all PTRF 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 47-390
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原理
- Anti-PTRF/CAVIN1 Antibody Picoband®
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交叉反应 （详细）
- No cross-reactivity with other proteins.
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产品特性
- Anti-PTRF/CAVIN1 Antibody Picoband® (ABIN7601817). Tested in ELISA, Flow Cytometry, IF, IHC, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
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纯化方法
- Immunogen affinity purified.
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免疫原
- E.coli-derived human PTRF/CAVIN1 recombinant protein (Position: D47-D390).
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亚型
- IgG
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anti-Polymerase I and Transcript Release Factor (PTRF) (Middle Region) antibody
PTRF 适用: 人, 小鼠, 大鼠, Cow, 马, 兔, 犬 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Polymerase I and Transcript Release Factor (PTRF) (AA 233-321) antibodyPTRF 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Polymerase I and Transcript Release Factor (PTRF) (AA 177-226) antibodyPTRF 适用: 人, 小鼠, Cow, 兔, Pig WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Polymerase I and Transcript Release Factor (PTRF) (AA 1-30) antibodyPTRF 适用: 人 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Polymerase I and Transcript Release Factor (PTRF) (AA 1-390) antibodyPTRF 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-Polymerase I and Transcript Release Factor (PTRF) (AA 1-390) antibodyPTRF 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Polymerase I and Transcript Release Factor (PTRF) (AA 233-321) antibodyPTRF 适用: 人 ELISA, IHC (p) 宿主: 小鼠 Monoclonal 1F7 unconjugated
anti-Polymerase I and Transcript Release Factor (PTRF) (Internal Region) antibodyPTRF 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Polymerase I and Transcript Release Factor (PTRF) (AA 1-30), (N-Term) antibodyPTRF 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB15455 unconjugated
anti-Polymerase I and Transcript Release Factor (PTRF) (AA 12-44) antibodyPTRF 适用: 人 ELISA, IF 宿主: 兔 Polyclonal unconjugated
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应用备注
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Western blot, 0.1-0.25 μg/mL, Human, Mouse, Rat
Immunohistochemistry(Paraffin-embedded Section), 1-2 μg/mL, Human, Mouse, Rat
Immunocytochemistry/Immunofluorescence, 5 μg/mL, Human
Flow Cytometry (Fixed), 1-3 μg/1x106 cells, Human
ELISA, 0.1-0.5 μg/mL, -
1. Hayashi, Y. K., Matsuda, C., Ogawa, M., Goto, K., Tominaga, K., Mitsuhashi, S., Park, Y.-E., Nonaka, I., Hino-Fukuyo, N., Haginoya, K., Sugano, H., Nishino, I. Human PTRF mutations cause secondary deficiency of caveolins resulting in muscular dystrophy with generalized lipodystrophy. J. Clin. Invest. 119: 2623-2633, 2009. 2. Hill, M. M., Bastiani, M., Luetterforst, R., Kirkham, M., Kirkham, A., Nixon, S. J., Walser, P., Abankawa, D., Oorschot, V. M. J., Martin, S., Hancock, J. F., Parton, R. G. PTRF-Cavin, a conserved cytoplasmic protein required for caveola formation and function. Cell 132: 113-124, 2008. 3. Jansa, P., Mason, S. W., Hoffmann-Rohrer, U., Grummt, I. Cloning and functional characterization of PTRF, a novel protein which induces dissociation of paused ternary transcription complexes. EMBO J. 17: 2855-2864, 1998. -
限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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浓度
- 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
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At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.
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- PTRF (Polymerase I and Transcript Release Factor (PTRF))
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别名
- CAVIN1
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背景
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Synonyms: Lymphocyte antigen 6A-2/6E-1,Ly-6A.2/Ly-6E.1,Stem cell antigen 1,SCA-1,T-cell-activating protein,TAP,Ly6a,Ly6,
Tissue Specificity: Widely expressed. .
Background: This gene encodes a protein that enables the dissociation of paused ternary polymerase I transcription complexes from the 3' end of pre-rRNA transcripts. This protein regulates rRNA transcription by promoting the dissociation of transcription complexes and the reinitiation of polymerase I on nascent rRNA transcripts. This protein also localizes to caveolae at the plasma membrane and is thought to play a critical role in the formation of caveolae and the stabilization of caveolins. This protein translocates from caveolae to the cytoplasm after insulin stimulation. Caveolae contain truncated forms of this protein and may be the site of phosphorylation-dependent proteolysis. This protein is also thought to modify lipid metabolism and insulin-regulated gene expression. Mutations in this gene result in a disorder characterized by generalized lipodystrophy and muscular dystrophy.
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分子量
- 50-55 kDa
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基因ID
- 284119
抗原
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