MSH2 抗体 (AA 337-583)
Quick Overview for MSH2 抗体 (AA 337-583) (ABIN7601369)
抗原
See all MSH2 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
-
-
抗原表位
- AA 337-583
-
原理
- Anti-MSH2 Antibody Picoband® (monoclonal, 6B4F7)
-
交叉反应 （详细）
- No cross-reactivity with other proteins.
-
产品特性
- Anti-MSH2 Antibody Picoband® (monoclonal, 6B4F7) (ABIN7601369). Tested in IF, IHC, ICC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
-
纯化方法
- Immunogen affinity purified.
-
免疫原
- E.coli-derived human MSH2 recombinant protein (Position: Q337-N583). Human MSH2 shares 94% and 93% amino acid (aa) sequence identity with mouse and rat MSH2, respectively.
-
亚型
- IgG2b
-
-
anti-Mismatch Repair Protein 2 (MSH2) (AA 327-427) antibody
MSH2 适用: 人 WB, IHC, FACS, StM 宿主: 小鼠 Monoclonal MSH2-2622 unconjugated
anti-Mismatch Repair Protein 2 (MSH2) (AA 1-300) antibodyMSH2 适用: 人 WB, IF, IP 宿主: 兔 Polyclonal unconjugated
anti-Mismatch Repair Protein 2 (MSH2) (AA 442-586) antibodyMSH2 适用: 人, 小鼠 WB, ELISA, IHC, FACS, ICC 宿主: 小鼠 Monoclonal 2E2C7 unconjugated
anti-Mismatch Repair Protein 2 (MSH2) (AA 1-934) antibodyMSH2 适用: 人 WB, IF, PLA 宿主: 兔 Polyclonal unconjugated
anti-Mismatch Repair Protein 2 (MSH2) (AA 337-583) antibodyMSH2 适用: 人, 小鼠, 大鼠 WB, IHC, IF, FACS, ICC 宿主: 兔 Polyclonal unconjugated
anti-Mismatch Repair Protein 2 (MSH2) (AA 835-934) antibodyMSH2 适用: 人 WB, ELISA, PLA 宿主: 小鼠 Monoclonal 4B2 unconjugated
anti-Mismatch Repair Protein 2 (MSH2) (AA 224-313) antibodyMSH2 适用: 人 IHC, StM 宿主: 小鼠 Monoclonal SYP-3551 unconjugated
anti-Mismatch Repair Protein 2 (MSH2) (AA 442-586) antibodyMSH2 适用: 人 ELISA, FACS 宿主: 小鼠 Monoclonal 4F10D6 unconjugated
anti-Mismatch Repair Protein 2 (MSH2) (AA 637-665) antibodyMSH2 适用: 人 WB, ELISA, IF, FACS 宿主: 兔 Polyclonal unconjugated
anti-Mismatch Repair Protein 2 (MSH2) (AA 2-254) antibodyMSH2 适用: 人 WB, ELISA, IHC, IP 宿主: 兔 Polyclonal unconjugated
-
-
应用备注
-
Western blot, 0.25-0.5 μg/mL, Human
Immunohistochemistry(Paraffin-embedded Section), 2-5 μg/mL, Human
Immunocytochemistry/Immunofluorescence, 5 μg/mL, Human
1. de Wind N, Dekker M, Berns A, Radman M, te Riele H (July 1995). "Inactivation of the mouse Msh2 gene results in mismatch repair deficiency, methylation tolerance, hyperrecombination, and predisposition to cancer". Cell 82 (2): 321-30. 2. Mellon I, Rajpal DK, Koi M, Boland CR, Champe GN (April 1996). "Transcription-coupled repair deficiency and mutations in human mismatch repair genes". Science 272 (5261): 557-60. 3. Wada-Hiraike, O., Yano, T., Nei, T., Matsumoto, Y., Nagasaka, K., Takizawa, S., Oishi, H., Arimoto, T., Nakagawa, S., Yasugi, T., Kato, S., Taketani, Y. The DNA mismatch repair gene hMSH2 is a potent coactivator of oestrogen receptor-alpha. Brit. J. Cancer 92: 2286-2291, 2005. -
限制
- 仅限研究用
-
-
-
状态
- Lyophilized
-
溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
-
浓度
- 500 μg/mL
-
缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.
-
储存条件
- 4 °C,-20 °C
-
储存方法
-
At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.
-
-
- MSH2 (Mismatch Repair Protein 2 (MSH2))
-
别名
- MSH2
-
背景
-
Synonyms: Cytosolic NADP isocitrate dehydrogenase antibody|Cytosolic NADP-isocitrate dehydrogenase antibody|Epididymis luminal protein 216 antibody|Epididymis secretory protein Li 26 antibody|HEL-216 antibody|HEL-S-26 antibody|ICDH antibody|IDCD antibody|IDH antibody|IDH1 antibody|IDHC_HUMAN antibody|IDP antibody|IDPC antibody|Isocitrate dehydrogenase [NADP] cytoplasmic antibody|Isocitrate dehydrogenase 1 (NADP+) soluble antibody|NADP dependent isocitrate dehydrogenase cytosolic antibody|NADP dependent isocitrate dehydrogenase peroxisomal antibody|NADP (+)-specific ICDH antibody|Oxalosuccinate decarboxylase antibody|PICD antibody
Tissue Specificity: Ubiquituous. Expressed in platelets.
Background: DNA mismatch repair protein Msh2, also known as MutS protein homolog 2 or MSH2, is a protein that in humans is encoded by the MSH2 gene, which is located on chromosome 2. MSH2 is a tumor suppressor gene and more specifically a caretaker gene that codes for a DNA mismatch repair (MMR) protein, MSH2 which forms aheterodimer with MSH6 to make the human MutSα mismatch repair complex. It also dimerizes with MSH3 to form the MutSβ DNA repair complex. MSH2 is involved in many different forms of DNA repair, including transcription-coupled repair, homologous recombination, and base excision repair. It has been found that MSH2 may also be a coactivator of ESR1-dependent gene expression.
-
分子量
- 105 kDa
-
基因ID
- 4436
-
UniProt
- P43246
-
途径
- DNA Damage Repair, Production of Molecular Mediator of Immune Response
抗原
-
