NOTCH2 抗体 (AA 2194-2471)
Quick Overview for NOTCH2 抗体 (AA 2194-2471) (ABIN7600664)
抗原
See all NOTCH2 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 2194-2471
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原理
- Anti-NOTCH2 Antibody Picoband®
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交叉反应 （详细）
- No cross-reactivity with other proteins.
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产品特性
- Anti-NOTCH2 Antibody Picoband® (ABIN7600664). Tested in ELISA, Flow Cytometry, IHC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
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纯化方法
- Immunogen affinity purified.
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免疫原
- E.coli-derived human NOTCH2 recombinant protein (Position: H2194-A2471).
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亚型
- IgG
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anti-Notch 2 (NOTCH2) antibody
NOTCH2 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Notch 2 (NOTCH2) (Asp1733), (cleaved) antibodyNOTCH2 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Notch 2 (NOTCH2) (C-Term) antibodyNOTCH2 适用: 人, 小鼠 WB, ChIP-seq 宿主: 兔 Polyclonal unconjugated
anti-Notch 2 (NOTCH2) (AA 1501-1700) antibodyNOTCH2 适用: 人, 小鼠 WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Notch 2 (NOTCH2) (Cleaved-Asp1733) antibodyNOTCH2 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Notch 2 (NOTCH2) (AA 59-250) antibodyNOTCH2 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Notch 2 (NOTCH2) (AA 2251-2466) antibodyNOTCH2 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Notch 2 (NOTCH2) (AA 2242-2471) antibodyNOTCH2 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Notch 2 (NOTCH2) (Cleaved-Ala1734) antibodyNOTCH2 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
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应用备注
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Western blot, 0.25-0.5 μg/mL
Immunohistochemistry, 2-5 μg/mL
Flow Cytometry (Fixed), 1-3 μg/1x106 cells
ELISA, 0.1-0.5 μg/mL
1. Blaumueller, C. M., Qi, H., Zagouras, P., Artavanis-Tsakonas, S. Fixed cleavage of Notch leads to a heterodimeric receptor on the plasma membrane. Cell 90: 281-291, 1997. 2. Gao, X., Copeland, N. G., Gilbert, D. J., Jenkins, N. A., Gridley, T. Assignment of the murine Notch2 and Notch3 genes to chromosomes 3 and 17. Genomics 49: 160-161, 1998. -
限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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浓度
- 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
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Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
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- NOTCH2 (Notch 2 (NOTCH2))
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别名
- NOTCH2
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背景
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Synonyms: Neurogenic locus notch homolog protein 2, Notch 2, Hn2, Notch 2 extracellular truncation, N2ECD, Notch 2 intracellular domain, N2ICD, NOTCH2
Tissue Specificity: Expressed in the brain, heart, kidney, lung, skeletal muscle and liver. Ubiquitously expressed in the embryo.
Background: Neurogenic locus notch homolog protein 2 also known as notch 2 is a protein that in humans is encoded by the NOTCH2 gene. It is mapped to 1p12. This gene encodes a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signaling pathway that plays a key role in development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remain to be determined. This protein is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. This protein functions as a receptor for membrane bound ligands, and may play a role in vascular, renal and hepatic development. Two transcript variants encoding different isoforms have been found for this gene.
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分子量
- 110 kDa, 300 kDa
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基因ID
- 4853
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UniProt
- Q04721
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途径
- Notch Signaling, Stem Cell Maintenance
抗原
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