Thrombospondin 1 抗体 (AA 19-268)
Quick Overview for Thrombospondin 1 抗体 (AA 19-268) (ABIN7600407)
抗原
See all Thrombospondin 1 (THBS1) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 19-268
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原理
- Anti-Thrombospondin/THBS1 Antibody Picoband®
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交叉反应 （详细）
- No cross-reactivity with other proteins.
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产品特性
- Anti-Thrombospondin/THBS1 Antibody Picoband® (ABIN7600407). Tested in ELISA, Flow Cytometry, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
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纯化方法
- Immunogen affinity purified.
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免疫原
- E.coli-derived human Thrombospondin/THBS1 recombinant protein (Position: N19-A268).
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亚型
- IgG
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anti-Thrombospondin 1 (THBS1) (AA 80-360) antibody
THBS1 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Thrombospondin 1 (THBS1) (AA 515-671) antibodyTHBS1 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Thrombospondin 1 (THBS1) (N-Term) antibodyVerified THBS1 适用: 人, 小鼠 WB, IHC, ELISA, IF, FACS 宿主: 山羊 Polyclonal unconjugated
anti-Thrombospondin 1 (THBS1) (AA 24-221) antibodyTHBS1 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Thrombospondin 1 (THBS1) (AA 71-259) antibodyTHBS1 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Thrombospondin 1 (THBS1) (AA 750-850) antibodyTHBS1 适用: 人 ELISA, FACS 宿主: 小鼠 Monoclonal 5E2E2 unconjugated
anti-Thrombospondin 1 (THBS1) (AA 61-259) antibodyTHBS1 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Thrombospondin 1 (THBS1) antibodyTHBS1 适用: 小鼠 IHC 宿主: 兔 Polyclonal unconjugated
anti-Thrombospondin 1 (THBS1) (AA 1-1170) antibodyTHBS1 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-Thrombospondin 1 (THBS1) antibodyTHBS1 适用: 人, 小鼠 IHC, ELISA 宿主: 兔 Polyclonal unconjugated
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应用备注
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Western blot, 0.25-0.5 μg/mL, Human
Flow Cytometry (Fixed), 1-3 μg/1x106 cells, Human
ELISA, 0.1-0.5 μg/mL, -
1. Blake SM, Strasser V, Andrade N et al. (October 2008). "Thrombospondin-1 binds to ApoER2 and VLDL receptor and functions in postnatal neuronal migration". The EMBO Journal 27 (22): 3069-80. 2. Lopez-Dee ZP, Chittur SV, Patel B, Stanton R, Wakeley M, Lippert B, Menaker A, Eiche B, Terry R, Gutierrez LS (2012)."Thrombospondin-1 type 1 repeats in a model of inflammatory bowel disease: transcript profile and therapeutic effects". PLoS ONE7 (4): e34590. 3. Simantov R, Silverstein RL (September 2003). "CD36: a critical anti-angiogenic receptor". Frontiers in bioscience : a journal and virtual library 8 (1-3): s874-82. -
限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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浓度
- 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.01 mg Sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
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Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
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- Thrombospondin 1 (THBS1)
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别名
- THBS1
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背景
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Synonyms: Thrombospondin-1,THBS1,TSP, TSP1,
Tissue Specificity: Expressed in natural killer (NK) cells, CD8 (+) alpha-beta and gamma-delta T-cells. Expressed on essentially all CD56+CD3- NK cells from freshly isolated PBMC. Expressed in interferon-producing killer dendritic cells (IKDCs).
Background: THBS1 is also known as Thrombospondin 1, TSP1. The protein encoded by this gene is a subunit of a disulfide-linked homotrimeric protein. It is an adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Also this protein can bind to fibrinogen, fibronectin, laminin, type V collagen and integrins alpha-V/beta-1. This protein has been shown to play roles in platelet aggregation, angiogenesis, and tumorigenesis. In addition, the thrombospondin-1 protein is a member of the thrombospondinfamily. It is a multi-domain matrix glycoprotein that has been shown to be a natural inhibitor of neovascularization and tumorigenesis in healthy tissue. Both positive and negative modulation of endothelial cell adhesion, motility, and growth have been attributed to TSP1. This should not be surprising considering that TSP1 interacts with at least 12 cell adhesion receptors, including CD36, αv integrins, β1 integrins, syndecan, and integrin-associated protein (IAP or CD47). It also interacts with numerous proteases involved in angiogenesis, including plasminogen, urokinase, matrix metalloproteinase, thrombin, cathepsin, and elastase.
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分子量
- 129 kDa
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基因ID
- 7057
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UniProt
- P07996
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途径
- Autophagy
抗原
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