HNF4A 抗体 (AA 164-474)
Quick Overview for HNF4A 抗体 (AA 164-474) (ABIN7600215)
抗原
See all HNF4A 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 164-474
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原理
- Anti-HNF-4-alpha Antibody Picoband® (monoclonal, 6C8E9)
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交叉反应 （详细）
- No cross-reactivity with other proteins.
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产品特性
- Anti-HNF-4-alpha Antibody Picoband® (monoclonal, 6C8E9) (ABIN7600215). Tested in IHC, WB applications. This antibody reacts with Human, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
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纯化方法
- Immunogen affinity purified.
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免疫原
- E.coli-derived human HNF-4-alpha recombinant protein (Position: Q164-I474). Human HNF-4-alpha shares 95% and 96% amino acid (aa) sequence identity with mouse and rat HNF-4-alpha, respectively.
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亚型
- IgG2a
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anti-Hepatocyte Nuclear Factor 4, alpha (HNF4A) (AA 324-423) antibody
HNF4A 适用: 人 WB, ELISA, IF, RNAi 宿主: 小鼠 Monoclonal 4E2 unconjugated
anti-Hepatocyte Nuclear Factor 4, alpha (HNF4A) (N-Term) antibodyHNF4A 适用: 人, 小鼠, 大鼠, Cow, 犬, 马, 兔, 豚鼠, 绵羊, 斑马鱼 WB 宿主: 兔 Polyclonal unconjugated
anti-Hepatocyte Nuclear Factor 4, alpha (HNF4A) (pSer313) antibodyHNF4A 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Hepatocyte Nuclear Factor 4, alpha (HNF4A) (AA 1-464) antibodyHNF4A 适用: 人 WB, PLA 宿主: 兔 Polyclonal unconjugated
anti-Hepatocyte Nuclear Factor 4, alpha (HNF4A) (AA 281-312) antibodyHNF4A 适用: 人, 大鼠 WB, ELISA, IHC, IF, FACS 宿主: 兔 Polyclonal unconjugated
anti-Hepatocyte Nuclear Factor 4, alpha (HNF4A) (AA 1-464) antibodyHNF4A 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-Hepatocyte Nuclear Factor 4, alpha (HNF4A) (AA 200-300) antibodyHNF4A 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Hepatocyte Nuclear Factor 4, alpha (HNF4A) (C-Term) antibodyHNF4A 适用: 人, 猴 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Hepatocyte Nuclear Factor 4, alpha (HNF4A) (N-Term) antibodyVerified HNF4A 适用: 人 WB, ELISA, IHC 宿主: 山羊 Polyclonal unconjugated
anti-Hepatocyte Nuclear Factor 4, alpha (HNF4A) (Middle Region) antibodyHNF4A 适用: 人, 小鼠, 大鼠, Cow, Pig, 犬, 马, 兔, 豚鼠, 绵羊, 斑马鱼 WB, IHC 宿主: 兔 Polyclonal unconjugated
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应用备注
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Western blot, 0.25-0.5 μg/mL, Human, Rat
Immunohistochemistry(Paraffin-embedded Section), 2-5 μg/mL, Rat
1. Chartier FL, Bossu JP, Laudet V, Fruchart JC, Laine B (September 1994). "Cloning and sequencing of cDNAs encoding the human hepatocyte nuclear factor 4 indicate the presence of two isoforms in human liver". Gene 147 (2): 269-72. 2. Argyrokastritis A, Kamakari S, Kapsetaki M, Kritis A, Talianidis I, Moschonas NK (February 1997). "Human hepatocyte nuclear factor-4 (hHNF-4) gene maps to 20q12-q13.1 between PLCG1 and D20S17". Hum. Genet. 99 (2): 233-6. 3. Tirona RG, Lee W, Leake BF, Lan LB, Cline CB, Lamba V, Parviz F, Duncan SA, Inoue Y, Gonzalez FJ, Schuetz EG, Kim RB (February 2003). "The orphan nuclear receptor HNF4alpha determines PXR- and CAR-mediated xenobiotic induction of CYP3A4". Nat. Med. 9 (2): 220-4. -
限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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浓度
- 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
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At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.
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- HNF4A (Hepatocyte Nuclear Factor 4, alpha (HNF4A))
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别名
- HNF4A
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背景
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Synonyms: AHUS2 antibody, Antigen defined by monoclonal antibody, TRA 2 10 antibody, Antigen identified by monoclonal antibody, TRA 2 10 antibody, CD46 antibody, CD46 antigen antibody, CD46 antigen complement regulatory protein antibody, CD46 Molecule antibody, CD46 Molecule complement regulatory protein antibody, Complement membrane cofactor protein antibody, MCP antibody, MCP_HUMAN antibody, Measles virus receptor antibody, membrane cofactor protein (CD46, trophoblast-lymphocyte cross-reactive antigen) antibody, Membrane cofactor protein antibody, MGC26544 antibody,MIC10 antibody, TLX antibody, TRA2.10 antibody, Trophoblast leucocyte common antigen antibody, Trophoblast leukocyte common antigen antibody, Trophoblast lymphocyte cross reactive antigen antibody
Tissue Specificity: Expressed by all cells except erythrocytes.
Background: Hepatocyte nuclear factor 4 alpha (HNF4A), also known as NR2A1, is a nuclear receptor that in humans is encoded by the HNF4A gene. It is mapped to 20q13.12. HNF4A is a nuclear transcription factor that binds DNA as a homodimer. The encoded protein controls the expression of several genes, including hepatocyte nuclear factor 1 alpha, a transcription factor which regulates the expression of several hepatic genes. This gene plays a role in development of the liver, kidney, and intestines. HNF4A is required for the PXR and CAR-mediated transcriptional activation of CYP3A4. This gene also plays a pivotal role in the expression and synthesis of SHBG, an important glycoprotein made primarily in the liver, which in addition to lowering insulin-resistance also serves in reducing levels of free Oestrogen as-well as prolonging the half-life of Testosterone.
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分子量
- 53 kDa
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基因ID
- 3172
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UniProt
- P41235
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途径
- AMPK Signaling, Nuclear Receptor Transcription Pathway, Steroid Hormone Mediated Signaling Pathway, Carbohydrate Homeostasis, Cell-Cell Junction Organization, Regulation of Carbohydrate Metabolic Process
抗原
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