Angiotensin I Converting Enzyme 1 抗体 (AA 149-545)
Quick Overview for Angiotensin I Converting Enzyme 1 抗体 (AA 149-545) (ABIN7600092)
抗原
See all Angiotensin I Converting Enzyme 1 (ACE) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 149-545
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原理
- Anti-ACE Antibody Picoband®
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产品特性
- Anti-ACE Antibody Picoband® (ABIN7600092). Tested in WB, IHC, Flow Cytometry, ELISA applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
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纯化方法
- Immunogen affinity purified.
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免疫原
- E.coli-derived human ACE recombinant protein (Position: R149-C545). Human ACE shares 90.4% and 91.4% amino acid (aa) sequence identity with mouse and rat ACE, respectively.
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anti-Angiotensin I Converting Enzyme (Peptidyl-Dipeptidase A) 1 (ACE) (AA 1160-1306) antibody
ACE 适用: 人 WB, ELISA, ICC, IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Angiotensin I Converting Enzyme (Peptidyl-Dipeptidase A) 1 (ACE) (AA 814-1071) antibodyACE 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Angiotensin I Converting Enzyme (Peptidyl-Dipeptidase A) 1 (ACE) (AA 651-864) antibodyACE 适用: 人, 小鼠, 大鼠 WB, IHC, ICC, IHC (fro), IF 宿主: 兔 Polyclonal unconjugated
anti-Angiotensin I Converting Enzyme (Peptidyl-Dipeptidase A) 1 (ACE) (AA 801-900) antibodyACE 适用: 人, 小鼠, 大鼠, 犬 WB, ELISA, FACS, ICC, IF (p), IF (cc), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Angiotensin I Converting Enzyme (Peptidyl-Dipeptidase A) 1 (ACE) (AA 702-715), (Middle Region) antibodyACE 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Angiotensin I Converting Enzyme (Peptidyl-Dipeptidase A) 1 (ACE) (AA 592-701) antibodyACE 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 6A4 unconjugated
anti-Angiotensin I Converting Enzyme (Peptidyl-Dipeptidase A) 1 (ACE) (AA 592-701) antibodyACE 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 4B10 unconjugated
anti-Angiotensin I Converting Enzyme (Peptidyl-Dipeptidase A) 1 (ACE) antibodyACE 适用: 人 IHC, ELISA, Coat, StM 宿主: 小鼠 Monoclonal 9B9 unconjugated
anti-Angiotensin I Converting Enzyme (Peptidyl-Dipeptidase A) 1 (ACE) (AA 30-270) antibodyACE 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Angiotensin I Converting Enzyme (Peptidyl-Dipeptidase A) 1 (ACE) (AA 30-182) antibodyACE 适用: 人 ELISA 宿主: 小鼠 Monoclonal 3H7E4 unconjugated
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应用备注
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Western blot, 0.25-0.5 μg/mL, Mouse, Rat
Immunohistochemistry, 2-5 μg/mL, Human, Mouse
ELISA, 0.1-0.5 μg/mL, -
1. Alfalah, M., Parkin, E. T., Jacob, R., Sturrock, E. D., Mentele, R., Turner, A. J., Hooper, N. M., Naim, H. Y. A point mutation in the juxtamembrane stalk of human angiotensin I-converting enzyme invokes the action of a distinct secretase. J. Biol. Chem. 276: 21105-21109, 2001. 2. Amant, C., Bauters, C., Bodart, J.-C., Lablanche, J.-M., Grollier, G., Danchin, N., Hamon, M., Richard, F., Helbecque, N., McFadden, E. P., Amouyel, P., Bertrand, M. E. D allele of the angiotensin I-converting enzyme is a major risk factor for restenosis after coronary stenting. Circulation 96: 56-60, 1997. 3. Arbustini, E., Grasso, M., Fasani, R., Klersy, C., Diegoli, M., Porcu, E., Banchieri, N., Fortina, P., Danesino, C., Specchia, G. Angiotensin converting enzyme gene deletion allele is independently and strongly associated with coronary atherosclerosis and myocardial infarction. Brit. Heart J. 74: 584-591, 1995. -
限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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浓度
- 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
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At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.
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- Angiotensin I Converting Enzyme 1 (ACE) (Angiotensin I Converting Enzyme (Peptidyl-Dipeptidase A) 1 (ACE))
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别名
- ACE
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背景
- This gene encodes an enzyme involved in blood pressure regulation and electrolyte balance. It catalyzes the conversion of angiotensin I into a physiologically active peptide angiotensin II. Angiotensin II is a potent vasopressor and aldosterone-stimulating peptide that controls blood pressure and fluid-electrolyte balance. This angiotensin converting enzyme (ACE) also inactivates the vasodilator protein, bradykinin. Accordingly, the encoded enzyme increases blood pressure and is a drug target of ACE inhibitors, which are often prescribed to reduce blood pressure. This enzyme additionally plays a role in fertility through its ability to cleave and release GPI-anchored membrane proteins in spermatozoa. Many studies have associated the presence or absence of a 287 bp Alu repeat element in this gene with the levels of circulating enzyme. This polymorphism, as well as mutations in this gene, have been implicated in a wide variety of diseases including cardiovascular pathophysiologies, psoriasis, renal disease, stroke, and Alzheimer's disease. Regulation of the homologous ACE2 gene may be involved in progression of disease caused by several human coronaviruses, including SARS-CoV and SARS-CoV-2. Alternative splicing results in multiple transcript variants encoding both somatic (sACE) and male-specific testicular (tACE) isoforms.
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分子量
- 150-180 kDa
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基因ID
- 1636
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UniProt
- P12821
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途径
- ACE Inhibitor Pathway, Peptide Hormone Metabolism, Regulation of Systemic Arterial Blood Pressure by Hormones, Feeding Behaviour, Smooth Muscle Cell Migration
抗原
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