CLK2 抗体 (AA 140-496)
Quick Overview for CLK2 抗体 (AA 140-496) (ABIN7600043)
抗原
See all CLK2 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 140-496
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原理
- Anti-CLK2 Antibody Picoband®
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交叉反应 （详细）
- No cross-reactivity with other proteins.
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产品特性
- Anti-CLK2 Antibody Picoband® (ABIN7600043). Tested in ELISA, Flow Cytometry, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
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纯化方法
- Immunogen affinity purified.
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免疫原
- E.coli-derived human CLK2 recombinant protein (Position: A140-D496).
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亚型
- IgG
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anti-CDC-Like Kinase 2 (CLK2) (N-Term) antibody
CLK2 适用: 人, 小鼠, 大鼠 WB, ELISA, ICC, IF 宿主: 兔 Polyclonal unconjugated
anti-CDC-Like Kinase 2 (CLK2) (N-Term) antibodyCLK2 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-CDC-Like Kinase 2 (CLK2) (AA 240-499) antibodyCLK2 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-CDC-Like Kinase 2 (CLK2) (N-Term) antibodyCLK2 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-CDC-Like Kinase 2 (CLK2) (AA 1-498) antibodyCLK2 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-CDC-Like Kinase 2 (CLK2) (AA 66-93), (N-Term) antibodyCLK2 适用: 小鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-CDC-Like Kinase 2 (CLK2) (AA 1-30), (N-Term) antibodyCLK2 适用: 人 WB 宿主: 兔 Polyclonal RB3205 unconjugated
anti-CDC-Like Kinase 2 (CLK2) (N-Term) antibodyCLK2 适用: 人, 猴 WB, IHC 宿主: 兔 Polyclonal unconjugated
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应用备注
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Western blot, 0.1-0.25 μg/mL, Human, Mouse, Rat
Flow Cytometry (Fixed), 1-3 μg/1x106 cells, Human
ELISA, 0.1-0.5 μg/mL, -
1. Bidinosti, M., Botta, P., Kruttner, S., Proenca, C. C., Stoehr, N., Bernhard, M., Fruh, I., Mueller, M., Bonenfant, D., Voshol, H., Carbone, W., Neal, S. J., McTighe, S. M., Roma, G., Dolmetsch, R. E., Porter, J. A., Caroni, P., Bouwmeester, T., Luthi, A., Galimberti, I. CLK2 inhibition ameliorates autistic features associated with SHANK3 deficiency. Science 351: 1199-1203, 2016. 2. Hanes, J., von der Kammer, H., Klaudiny, J., Scheit, K. H. Characterization by cDNA cloning of two new human protein kinases: evidence by sequence comparison of a new family of mammalian protein kinases. J. Molec. Biol. 244: 665-672, 1994. 3. Nothwang, H. G., Kim, H. G., Aoki, J., Geisterfer, M., Kubart, S., Wegner, R. D., van Moers, A., Ashworth, L. K., Haaf, T., Bell, J., Arai, H., Tommerup, N., Ropers, H. H., Wirth, J. Functional hemizygosity of PAFAH1B3 due to a PAFAH1B3-CLK2 fusion gene in a female with mental retardation, ataxia and atrophy of the brain. Hum. Molec. Genet. 10: 797-806, 2001. -
限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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浓度
- 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg NaN3.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
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Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
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- CLK2 (CDC-Like Kinase 2 (CLK2))
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别名
- CLK2
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背景
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Synonyms: Dual specificity protein kinase CLK2, CDC-like kinase 2, CLK2
Tissue Specificity: Endothelial cells. Expressed in androgen-dependent prostate cancer cells.
Background: Dual specificity protein kinase CLK2 is an enzyme that in humans is encoded by the CLK2 gene. It is mapped to 1q22. This gene encodes a dual specificity protein kinase that phosphorylates serine/threonine and tyrosine-containing substrates. Activity of this protein regulates serine- and arginine-rich (SR) proteins of the spliceosomal complex, thereby influencing alternative transcript splicing. Chromosomal translocations have been characterized between this locus and the PAFAH1B3 (platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29 kDa)) gene on chromosome 19, resulting in the production of a fusion protein. Note that this gene is distinct from the TELO2 gene (GeneID:9894), which shares the CLK2 alias, but encodes a protein that is involved in telomere length regulation. There is a pseudogene for this gene on chromosome 7. Alternative splicing results in multiple transcript variants.
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分子量
- 60 kDa
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基因ID
- 1196
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UniProt
- P49760
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途径
- Regulation of Carbohydrate Metabolic Process
抗原
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