PTBP1 抗体 (AA 1-504)
Quick Overview for PTBP1 抗体 (AA 1-504) (ABIN7599450)
抗原
See all PTBP1 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 1-504
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原理
- Anti-PTBP1 Antibody Picoband®(monoclonal, 3H12)
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交叉反应 （详细）
- No cross-reactivity with other proteins.
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产品特性
- Anti-PTBP1 Antibody Picoband® (monoclonal, 3H12) (ABIN7599450). Tested in Flow Cytometry, IF, IHC, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
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纯化方法
- Immunogen affinity purified.
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免疫原
- E.coli-derived human PTBP1 recombinant protein (Position: M1-A504).
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亚型
- IgG2b
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anti-Polypyrimidine Tract Binding Protein 1 (PTBP1) (AA 45-144) antibody
PTBP1 适用: 人 WB, ELISA, IF, IP, IHC (p) 宿主: 小鼠 Monoclonal 3H8 unconjugated
anti-Polypyrimidine Tract Binding Protein 1 (PTBP1) (N-Term) antibodyVerified PTBP1 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA 宿主: 山羊 Polyclonal unconjugated
anti-Polypyrimidine Tract Binding Protein 1 (PTBP1) (AA 1-100) antibodyPTBP1 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Polypyrimidine Tract Binding Protein 1 (PTBP1) (AA 1-290) antibodyPTBP1 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Polypyrimidine Tract Binding Protein 1 (PTBP1) antibodyPTBP1 适用: 人 WB, IHC, IF 宿主: 兔 Monoclonal unconjugated
anti-Polypyrimidine Tract Binding Protein 1 (PTBP1) antibodyPTBP1 适用: 人 WB, IHC, ELISA 宿主: 兔 Monoclonal 8A1 unconjugated Recombinant Antibody
anti-Polypyrimidine Tract Binding Protein 1 (PTBP1) (N-Term) antibodyPTBP1 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Polypyrimidine Tract Binding Protein 1 (PTBP1) (AA 26-55), (N-Term) antibodyPTBP1 适用: 人 WB 宿主: 兔 Polyclonal RB40967 unconjugated
anti-Polypyrimidine Tract Binding Protein 1 (PTBP1) (AA 1-557) antibodyPTBP1 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-Polypyrimidine Tract Binding Protein 1 (PTBP1) (AA 45-145) antibodyPTBP1 适用: 人 WB, IHC, ELISA, IF, IHC (p) 宿主: 小鼠 Monoclonal 3H8 unconjugated
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应用备注
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Western blot, 0.1-0.5 μg/mL, Human, Mouse, Rat
Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL, Human, Mouse, Rat
Immunocytochemistry/Immunofluorescence, 2 μg/mL, Human
Immunofluorescence, 2 μg/mL, Human, Rat
Flow Cytometry (Fixed), 1-3 μg/1x106 cells, Human
1. Charlet-B., N., Logan, P., Singh, G., Cooper, T. A. Dynamic antagonism between ETR-3 and PTB regulates cell type-specific alternative splicing. Molec. Cell 9: 649-658, 2002. 2. David, C. J., Chen, M., Assanah, M., Canoll, P., Manley, J. L. HnRNP proteins controlled by c-Myc deregulate pyruvate kinase mRNA splicing in cancer. Nature 463: 364-368, 2010. 3. Ghetti, A., Pinol-Roma, S., Michael, W. M., Morandi, C., Dreyfuss, G. HNRNP I, the polypyrimidine tract-binding protein: distinct nuclear localization and association with hnRNAs. Nucleic Acids Res. 20: 3671-3678, 1992. -
限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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浓度
- 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg NaN3.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
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Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
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- PTBP1 (Polypyrimidine Tract Binding Protein 1 (PTBP1))
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别名
- PTBP1
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背景
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Synonyms: Polypyrimidine tract-binding protein 1, PTB, 57 kDa RNA-binding protein PPTB-1, Heterogeneous nuclear ribonucleoprotein I, hnRNP I, PTBP1, PTB
Tissue Specificity: Widely expressed in fetal and adult tissues.
Background: Polypyrimidine tract-binding protein 1 is a protein that in humans is encoded by the PTBP1 gene. It is mapped to 19p13.3. This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA-binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has four repeats of quasi-RNA recognition motif (RRM) domains that bind RNAs. This protein binds to the intronic polypyrimidine tracts that requires pre-mRNA splicing and acts via the protein degradation ubiquitin-proteasome pathway. It may also promote the binding of U2 snRNP to pre-mRNAs. This protein is localized in the nucleoplasm and it is also detected in the perinucleolar structure. Alternatively spliced transcript variants encoding different isoforms have been described.
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分子量
- 57 kDa
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基因ID
- 5725
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UniProt
- P26599
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途径
- Regulation of Muscle Cell Differentiation
抗原
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