PAK3 抗体 (AA 1-263)
Quick Overview for PAK3 抗体 (AA 1-263) (ABIN7599182)
抗原
See all PAK3 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 1-263
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原理
- Anti-PAK3 Antibody Picoband®
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交叉反应 （详细）
- No cross-reactivity with other proteins.
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产品特性
- Anti-PAK3 Antibody Picoband® (ABIN7599182). Tested in ELISA, Flow Cytometry, IF, IHC, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
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纯化方法
- Immunogen affinity purified.
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免疫原
- E.coli-derived human PAK3 recombinant protein (Position: M1-D263).
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亚型
- IgG
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anti-PAK3 (PAK3) (AA 1-90) antibody
PAK3 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 3A12 unconjugated
anti-PAK3 (PAK3) (AA 1-100) antibodyPAK3 适用: 人, 猴 WB, ELISA 宿主: 小鼠 Monoclonal 4G8F11 unconjugated
anti-PAK3 (PAK3) (AA 124-152) antibodyPAK3 适用: 人, 小鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-PAK3 (PAK3) (AA 70-190) antibodyPAK3 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-PAK3 (PAK3) antibodyPAK3 适用: 人 WB, IHC 宿主: 兔 Monoclonal unconjugated
anti-PAK3 (PAK3) (Ser154) antibodyPAK3 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-PAK3 (PAK3) (AA 1-100) antibodyPAK3 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-PAK3 (PAK3) (AA 124-152), (N-Term) antibodyPAK3 适用: 小鼠 WB, IHC (p) 宿主: 兔 Polyclonal RB34657 unconjugated
anti-PAK3 (PAK3) (AA 218-247) antibodyPAK3 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-PAK3 (PAK3) antibodyPAK3 适用: 人, 小鼠, 大鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
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应用备注
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Western blot, 0.25-0.5 μg/mL, Human, Mouse, Rat
Immunohistochemistry(Paraffin-embedded Section), 2-5 μg/mL, Human, Mouse, Rat
Immunocytochemistry/Immunofluorescence, 5 μg/mL, Human
Flow Cytometry (Fixed), 1-3 μg/1x106 cells, Human
ELISA, 0.1-0.5 μg/mL, -
1. "Entrez Gene: PAK3 p21 (CDKN1A)-activated kinase 3". 2. Allen KM, Gleeson JG, Bagrodia S, Partington MW, MacMillan JC, Cerione RA, Mulley JC, Walsh CA (Oct 1998). "PAK3 mutation in nonsyndromic X-linked mental retardation". Nat Genet 20 (1): 25-30. 3. Donnelly AJ, Partington MW, Ryan AK, Mulley JC (Nov 1996). "Regional localisation of two non-specific X-linked mental retardation genes (MRX30 and MRX31)". Am J Med Genet 64 (1): 113-20. -
限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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浓度
- 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
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At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.
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- PAK3
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别名
- PAK3
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背景
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Synonyms: Eosinophil cationic protein, ECP, Ribonuclease 3, RNase 3, RNASE3, ECP, RNS3
Tissue Specificity: Mainly expressed in pachytene spermatocytes of testis and in lymphocyte-rich areas of spleen and lymph nodes. Isoform v1 is expressed in spleen. Isoform v2 is expressed in testis. Also detected in ovary, placenta, pancreas, cardiac fibroblasts. Expressed in B-cells and prostate malignant cells. Isoform v1 and isoform v3 are expressed in epithelial colorectal adenocarcinoma cells. Isoform v2 and isoform v4 are expressed in endothelial cells. Isoform v1, isoform v2, isoform v3 and isoform v4 are expressed in pulmonary artery smooth muscle cells. Isoform v2 and isoform v5 are expressed in microvascular endothelial cells (at protein level).
Background: Serine/threonine-protein kinase PAK 3is anenzymethat in humans is encoded by thePAK3gene. PAK proteins are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. PAK proteins, a family of serine/threonine p21-activating kinases, serve as targets for the small GTP binding proteins Cdc42 and RAC and have been implicated in a wide range of biological activities. The protein encoded by this gene forms an activated complex with GTP-bound RAS-like (P21), CDC2 and RAC1 proteins which then catalyzes a variety of targets. This protein may be necessary for dendritic development and for the rapid cytoskeletal reorganization in dendritic spines associated with synaptic plasticity. Defects in this gene are the cause of non-syndromic mental retardation X-linked type 30 (MRX30), also called X-linked mental retardation type 47 (MRX47). Alternatively spliced transcript variants encoding different isoforms have been identified.
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分子量
- 62 kDa
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基因ID
- 5063
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UniProt
- O75914
抗原
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