SIGMAR1 抗体 (AA 1-154)
Quick Overview for SIGMAR1 抗体 (AA 1-154) (ABIN7599011)
抗原
See all SIGMAR1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 1-154
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原理
- Anti-Sigma1-receptor/SIGMAR1 Antibody Picoband®
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交叉反应 （详细）
- No cross-reactivity with other proteins
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产品特性
- Anti-Sigma1-receptor/SIGMAR1 Antibody Picoband® (ABIN7599011). Tested in ELISA, IHC, WB applications. This antibody reacts with Human, Monkey, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
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纯化方法
- Immunogen affinity purified.
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免疫原
- E.coli-derived human Sigma1-receptor/SIGMAR1 recombinant protein (Position: G1-H154).
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亚型
- IgG
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anti-sigma Non-Opioid Intracellular Receptor 1 (SIGMAR1) (AA 47-81), (N-Term) antibody
SIGMAR1 适用: 人 WB, FACS 宿主: 兔 Polyclonal RB14256 unconjugated
anti-sigma Non-Opioid Intracellular Receptor 1 (SIGMAR1) (AA 21-120) antibodySIGMAR1 适用: 人, 小鼠, 大鼠 WB, ELISA, ICC, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-sigma Non-Opioid Intracellular Receptor 1 (SIGMAR1) (AA 112-169) antibodySIGMAR1 适用: 人 IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-sigma Non-Opioid Intracellular Receptor 1 (SIGMAR1) (AA 31-80) antibodySIGMAR1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-sigma Non-Opioid Intracellular Receptor 1 (SIGMAR1) (AA 118-147) antibodySIGMAR1 适用: 人, 小鼠 WB 宿主: 兔 Polyclonal RB14335 unconjugated
anti-sigma Non-Opioid Intracellular Receptor 1 (SIGMAR1) (AA 113-126), (Intracellular) antibodyKO Validated SIGMAR1 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
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应用备注
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Western blot, 0.1-0.25 μg/mL, Human, Monkey, Mouse
Immunohistochemistry(Paraffin-embedded Section), 2-5 μg/mL, Human, Mouse, Rat
ELISA, 0.1-0.5 μg/mL, -
1. Al-Saif, A., Al-Mohanna, F., Bohlega, S. A mutation in sigma-1 receptor causes juvenile amyotrophic lateral sclerosis. Ann. Neurol. 70: 913-919, 2011. 2. Aydar, E., Palmer, C. P., Klyachko, V. A., Jackson, M. B. The sigma receptor as a ligand-regulated auxiliary potassium channel subunit. Neuron 34: 399-410, 2002. 3. Belzil, V. V., Daoud, H., Camu, W., Strong, M. J., Dion, P. A., Rouleau, G. A. Genetic analysis of SIGMAR1 as a cause of familial ALS with dementia. Europ. J. Hum. Genet. 21: 237-239, 2013. -
限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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浓度
- 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
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At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.
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- SIGMAR1 (sigma Non-Opioid Intracellular Receptor 1 (SIGMAR1))
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别名
- SIGMAR1
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背景
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Synonyms: Heat shock protein beta-8,HspB8,Alpha-crystallin C chain,E2-induced gene 1 protein,Protein kinase H11,Small stress protein-like protein HSP22,HSPB8,CRYAC, E2IG1, HSP22,PP1629,
Tissue Specificity: Predominantly expressed in skeletal muscle and heart. .
Background: The sigma-1 receptor (σ1R), one of two sigma receptor subtypes, is a chaperone protein at the endoplasmic reticulum (ER) that modulates calcium signaling through the IP3 receptor. In humans, the σ1 receptor is encoded by the SIGMAR1 gene. This gene encodes a receptor protein that interacts with a variety of psychotomimetic drugs, including cocaine and amphetamines. The receptor is believed to play an important role in the cellular functions of various tissues associated with the endocrine, immune, and nervous systems. As indicated by its previous name, opioid receptor sigma 1 (OPRS1), the product of this gene was erroneously thought to function as an opioid receptor, it is now thought to be a non-opioid receptor. Mutations in this gene has been associated with juvenile amyotrophic lateral sclerosis 16. Alternative splicing of this gene results in transcript variants encoding distinct isoforms.
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分子量
- 25 kDa
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基因ID
- 10280
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UniProt
- Q99720
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途径
- SARS-CoV-2 Protein Interactome
抗原
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