Ret Proto-Oncogene 抗体 (Extracellular) (FITC)
Quick Overview for Ret Proto-Oncogene 抗体 (Extracellular) (FITC) (ABIN7582071)
抗原
See all Ret Proto-Oncogene (RET) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 541-553, Extracellular
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原理
- A Rabbit Polyclonal Antibody to Ret receptor (extracellular) conjugated to the fluorescent dye FITC
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序列
- CEWRQGDGKG ITR
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特异性
- Extracellular, N-terminus
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预测反应
- Mouse - identical, rat - 12,13 amino acid residues identical
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产品特性
- Anti-Ret Receptor (extracellular) Antibody (ABIN7043600, ABIN7044783 and ABIN7044784) is a highly specific antibody directed against an extracellular epitope of the human Ret receptor. The antibody can be used in western blot, immunohistochemistry, immunocytochemistry and live cell flow cytometry applications. It has been designed to recognize Ret receptor from mouse, rat and human samples. Anti-Ret Receptor (extracellular)-FITC Antibody (ABIN7043600, ABIN7044783 and ABIN7044784-F) is directly conjugated to fluorescein isothiocyanate (FITC) fluorophore. This conjugated antibody has been developed to be used in immunofluorescent applications such as direct flow cytometry and live cell imaging. It has been designed to recognize Ret receptor from mouse, rat and human samples.
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纯化方法
- Affinity purified on immobilized antigen.
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免疫原
- CEWRQGDGKGITR, corresponding to amino acid residues 541-553 of human Ret
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亚型
- IgG
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anti-Ret Proto-Oncogene (RET) (AA 702-848) antibody
RET 适用: 人 IHC, StM 宿主: 小鼠 Monoclonal RET-2795 unconjugated
anti-Ret Proto-Oncogene (RET) (AA 1-1072) antibodyRET 适用: 人 WB, PLA 宿主: 兔 Polyclonal unconjugated
anti-Ret Proto-Oncogene (RET) (AA 702-848) antibodyRET 适用: 人 ELISA, Coat 宿主: 小鼠 Monoclonal RET-2663 unconjugated
anti-Ret Proto-Oncogene (RET) (AA 541-553), (Extracellular) antibodyRET 适用: 人 WB, IHC, IF, FACS, IC, LCI 宿主: 兔 Polyclonal unconjugated
anti-Ret Proto-Oncogene (RET) (pTyr1062) antibodyRET 适用: 人, 小鼠, 大鼠 WB, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Ret Proto-Oncogene (RET) (C-Term) antibodyRET 适用: 人, 小鼠, 大鼠 WB, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Ret Proto-Oncogene (RET) (AA 361-458) antibodyRET 适用: 人 WB, ELISA, PLA 宿主: 小鼠 Monoclonal 1A5 unconjugated
anti-Ret Proto-Oncogene (RET) (pTyr905) antibodyRET 适用: 人, 小鼠 WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Ret Proto-Oncogene (RET) (AA 1001-1114) antibodyRET 适用: 小鼠, 大鼠 WB, ELISA, IF (cc), IF (p), IHC (p), ICC, IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Ret Proto-Oncogene (RET) (AA 29-300) antibodyRET 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
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应用备注
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Antigen preadsorption control: 1 μg peptide per 1 μg antibody
Application Dilutions Immunohistochemistry paraffin embedded sections ihc: N/A
Application Dilutions Western blot wb: N/A
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说明
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Negative Control: (ABIN7582044)
Blocking Peptide: (ABIN7236725)
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- 15 μL or 50 μL double distilled water (DDW), depending on the sample size.
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浓度
- 1 mg/mL
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缓冲液
- PBS pH 7.4, 1 % BSA with 0.05 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
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Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.
Storage after reconstitution: The reconstituted solution can be stored at 4°C, protected from the light, for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
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- Ret Proto-Oncogene (RET)
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别名
- RET
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背景
- Proto-oncogene tyrosine-protein kinase receptor Ret, Proto-oncogene c-Ret, Cadherin family member 12, CDHF12, PTC, RET51,The RET proto-oncogene on human chromosome 10q11.2, encodes a receptor tyrosine kinase (RTK) activated by members of the glial cell line-derived neurotrophic factor (GDNF) ligand family (GDNF, neurturin, artemin, and persephin) in conjunction with a ligand-specific coreceptor (GFRα1-4)1. RET belongs to the cadherin superfamily, and it has been suggested that the ret gene is the result of a recombination between a gene encoding a tyrosine kinase receptor and a gene encoding an ancestral cadherin at an early stage of evolution2. The extracellular domain of RET comprises, as observed for other tyrosine kinase receptors, a cysteine-rich domain, but also four cadherin-like domains3.RET signaling is crucial for the development of the enteric nervous system. RET also regulates the development of sympathetic, parasympathetic, motor, and sensory neurons, and is necessary for the postnatal maintenance of dopaminergic neurons. Outside the nervous system, RET is crucial for development of the kidney and plays a key role in spermatogenesis4.RET has attracted considerable clinical interest because of the range of mutations found in diverse conditions that include Hirschsprung disease and a variety of cancers involving the thyroid gland. RET-related cancers with thyroid involvement include sporadic and familial medullary thyroid carcinoma (MTC), multiple endocrine neoplasia 2 (MEN2) syndromes MEN2A and MEN2B, and papillary thyroid carcinoma (PTC)5.
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基因ID
- 5979
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UniProt
- P07949
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途径
- RTK signaling, Dopaminergic Neurogenesis, Regulation of Cell Size, Tube Formation
抗原
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