NMNAT2 抗体 (Intracellular)
Our Local Distributor
北京 101111
Quick Overview for NMNAT2 抗体 (Intracellular) (ABIN7886674)
抗原
See all NMNAT2 抗体适用
宿主
克隆类型
标记
应用范围
-
-
抗原表位
- AA 131-146, Intracellular
-
原理
- A Rabbit polyclonal antibody to NMNAT2.
-
序列
- (C)HENTQPIYQN SNVPTK
-
预测反应
- Rat - identical,Human12,16 identical.
-
产品特性
- Anti-NMNAT2 Antibody (ABIN7581919) is a highly specific antibody directed against an epitope of the mouse protein. The antibody can be used in western blot and immunohistochemistry applications. It has been designed to recognize NMNAT2 from mouse, rat and human samples.
-
纯化方法
- Affinity purified on immobilized antigen.
-
免疫原
- (C)HENTQPIYQNSNVPTK, corresponding to amino acid residues 131 - 146 of mouse NMNAT2
-
亚型
- IgG
-
-
anti-Nicotinamide Nucleotide Adenylyltransferase 2 (NMNAT2) (AA 208-307) antibody
NMNAT2 适用: 人 ELISA, WB 宿主: 小鼠 Monoclonal 4E6 unconjugated
anti-Nicotinamide Nucleotide Adenylyltransferase 2 (NMNAT2) (AA 1-302) antibodyNMNAT2 适用: 人 ELISA, IF 宿主: 小鼠 Monoclonal 2G8 unconjugated
anti-Nicotinamide Nucleotide Adenylyltransferase 2 (NMNAT2) (AA 208-307) antibodyNMNAT2 适用: 人 ELISA, WB 宿主: 小鼠 Polyclonal unconjugated
anti-Nicotinamide Nucleotide Adenylyltransferase 2 (NMNAT2) (AA 1-153) antibodyNMNAT2 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Nicotinamide Nucleotide Adenylyltransferase 2 (NMNAT2) (AA 1-302) antibodyNMNAT2 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Nicotinamide Nucleotide Adenylyltransferase 2 (NMNAT2) antibodyNMNAT2 适用: 人 ELISA, WB, IHC 宿主: 小鼠 Monoclonal Nady-1 unconjugated
anti-Nicotinamide Nucleotide Adenylyltransferase 2 (NMNAT2) antibodyNMNAT2 适用: 人 ELISA, WB, IHC 宿主: 豚鼠 Polyclonal unconjugated
-
-
应用备注
- The optimal concentration should be determined by the user
-
限制
- 仅限研究用
-
-
-
状态
- Lyophilized
-
溶解方式
- 25 μL, 50 μL or 0.2 mL double distilled water (DDW), depending on the sample size.
-
浓度
- 0.8 mg/mL
-
缓冲液
- PBS pH 7.4, 1 % BSA with 0.05 % sodium azide
-
储存液
- Sodium azide
-
注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
储存条件
- -20 °C
-
储存方法
- The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C
-
-
- NMNAT2 (Nicotinamide Nucleotide Adenylyltransferase 2 (NMNAT2))
-
别名
- NMNAT2
-
背景
-
Synonyms: Nicotinamide mononucleotide adenylyltransferase 2, Nicotinamide Nucleotide Adenylyltransferase 2, Nicotinamide/Nicotinic Acid Mononucleotide Adenylyltransferase 2, NMN adenylyltransferase 2
Description: Nicotinamide mononucleotide adenylyltransferase 2, also referred to as NMNAT2, belongs to the NMNAT family of enzymes responsible for NAD+ biosynthesis. This family catalyzes the final step in NAD+ production, converting nicotinamide mononucleotide (NMN) and ATP to NAD+. NMNAT2 is predominantly localized in the cytoplasm and Golgi apparatus, distinguishing it from NMNAT1 (nuclear) and NMNAT3 (mitochondrial) counterparts. Structurally, NMNATs share conserved ATP-binding motifs crucial for their enzymatic functions1-3. In addition to its enzymatic role, NMNAT2 also functions as a chaperone, mitigating protein aggregation under proteotoxic stress. Its enzymatic and chaperone activities are recruited in a context-dependent manner, protecting against excitotoxicity and proteotoxic stress, respectively. This dual functionality highlights its significance in cellular stress responses5. NMNAT2 plays a critical role in cellular energy metabolism by maintaining NAD+ pools, essential for redox reactions and the activity of sirtuins and PARPs, key regulators of gene expression and stress responses. NMNAT2's cytoplasmic localization facilitates its involvement in glucose metabolism and the regulation of compartmentalized NAD+ availability, which is crucial for processes like adipogenesis4. In neurons, NMNAT2 contributes to axonal protection and integrity by modulating NAD+-dependent repair pathways, highlighting its neuroprotective roles5. NMNAT2 protein levels are tightly regulated post-transcriptionally, with a short half-life necessitating constant replenishment, and its expression is induced by glucose metabolism3. Tissue-specific expression studies reveal that NMNAT2 is highly abundant in the brain, heart, and skeletal muscle, reflecting its importance in energy-demanding tissues. At the cellular level, its expression is notable in neurons, cardiomyocytes, and other metabolically active cells3-5. Clinically, reduced NMNAT2 levels have been observed in neurodegenerative diseases like Alzheimer's, where its decline precedes neurodegeneration, underscoring its potential as a therapeutic target. Dysregulated NMNAT2 activity has also been implicated in cardiac hypertrophy, demonstrating its broad relevance in disease pathophysiology1,3,5.
-
基因ID
- 226518
-
UniProt
- Q8BNJ3
抗原
-
