Presenilin 1 抗体 (AA 10-80)
Quick Overview for Presenilin 1 抗体 (AA 10-80) (ABIN723770)
抗原
See all Presenilin 1 (PSEN1) 抗体适用
宿主
克隆类型
标记
应用范围
-
-
抗原表位
- AA 10-80
-
交叉反应
- 人, 小鼠, 大鼠
-
预测反应
- Dog,Cow,Pig,Rabbit
-
纯化方法
- Purified by Protein A.
-
免疫原
- KLH conjugated synthetic peptide derived from mouse Presenilin-1 NTF subunit
-
亚型
- IgG
-
-
anti-Presenilin 1 (PSEN1) (AA 1-160) antibody
PSEN1 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Presenilin 1 (PSEN1) (AA 330-359), (C-Term) antibodyPSEN1 适用: 人, 小鼠 WB, IHC (p), IF, FACS 宿主: 兔 Polyclonal RB2257 unconjugated
anti-Presenilin 1 (PSEN1) (AA 4-218) antibodyPSEN1 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Presenilin 1 (PSEN1) (Middle Region) antibodyPSEN1 适用: 人, 小鼠, 大鼠, Cow, 豚鼠, 犬, 马, 兔 WB, IHC, IP 宿主: 兔 Polyclonal unconjugated
anti-Presenilin 1 (PSEN1) (AA 1-160) antibodyPSEN1 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Presenilin 1 (PSEN1) (AA 300-349) antibodyPSEN1 适用: 人, 小鼠, 猴, Cow, Pig, 豚鼠, 马 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Presenilin 1 (PSEN1) (AA 107-156) antibodyPSEN1 适用: 人, 小鼠, 大鼠, 猴, Pig, 豚鼠, 犬, Bat, Hamster WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Presenilin 1 (PSEN1) (N-Term) antibodyPSEN1 适用: 人, 小鼠, 大鼠, Cow, 豚鼠, 犬, 马, 兔, 斑马鱼 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Presenilin 1 (PSEN1) (AA 299-350) antibodyPSEN1 适用: 人 WB, ELISA, IF (cc), IF (p), IHC (fro) 宿主: 小鼠 Polyclonal unconjugated
-
-
应用备注
-
WB 1:300-5000
ELISA 1:500-1000
FCM 1:20-100
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 -
限制
- 仅限研究用
-
-
-
状态
- Liquid
-
浓度
- 1 μg/μL
-
缓冲液
- 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
-
储存液
- ProClin
-
注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
-
储存条件
- 4 °C,-20 °C
-
储存方法
- Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
-
有效期
- 12 months
-
-
- Presenilin 1 (PSEN1)
-
别名
- Presenilin 1
-
背景
-
Synonyms: AD3, FAD, PS1, PS-1, S182, Presenilin-1, Protein S182, PSEN1, PSNL1
Background: Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). Requires the other members of the gamma-secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. Stimulates cell-cell adhesion though its association with the E-cadherin/catenin complex. Under conditions of apoptosis or calcium influx, cleaves E-cadherin promoting the disassembly of the E-cadherin/catenin complex and increasing the pool of cytoplasmic beta-catenin, thus negatively regulating Wnt signaling. May also play a role in hematopoiesis.
-
基因ID
- 5663
-
UniProt
- P49768
-
途径
- Notch Signaling, EGFR Signaling Pathway, Synaptic Vesicle Exocytosis, Dicarboxylic Acid Transport
抗原
-
