CBP 抗体 (N-Term)
Quick Overview for CBP 抗体 (N-Term) (ABIN7540638)
抗原
See all CBP (CREBBP) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- N-Term
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Supplier Product No.
- 600-401-mq0s
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Supplier
- Rockland
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原理
- CREBBP Antibody
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交叉反应 （详细）
- This affinity purified antibody is directed against human CREBBP.
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纯化方法
- The antibody was affinity purified from monospecific antiserum by immunoaffinity purification.
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过滤
- Sterile filtered
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免疫原
- Anti-CREBBP antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to an N-Terminal portion of human CREBBP conjugated to Keyhole Limpet Hemocyanin (KLH).
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亚型
- IgG
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anti-CREB Binding Protein (CREBBP) (C-Term) antibody
KO Validated CREBBP 适用: 人 WB, IF, IP, ICC, IHC (p), ChIP 宿主: 兔 Polyclonal unconjugated
anti-CREB Binding Protein (CREBBP) (C-Term) antibodyCREBBP 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-CREB Binding Protein (CREBBP) (AA 951-1050) antibodyCREBBP 适用: 人 WB, ELISA, IF, PLA 宿主: 小鼠 Monoclonal 2H5 unconjugated
anti-CREB Binding Protein (CREBBP) (AA 144-193) antibodyCREBBP 适用: 人, 小鼠, 大鼠, Cow, 犬, 兔, 小鸡, 豚鼠, 马 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-CREB Binding Protein (CREBBP) (N-Term) antibodyCREBBP 适用: 人, 小鼠, 大鼠, Cow, 犬, 兔, 豚鼠, 马 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-CREB Binding Protein (CREBBP) (C-Term) antibodyCREBBP 适用: 人 WB, IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-CREB Binding Protein (CREBBP) (AA 2217-2442) antibodyCREBBP 适用: 人 IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-CREB Binding Protein (CREBBP) antibodyCREBBP 适用: 人, 小鼠, 大鼠 IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-CREB Binding Protein (CREBBP) antibodyCREBBP 适用: 人 WB, IP, ICC, DB 宿主: 小鼠 Monoclonal CBP5I001 unconjugated
anti-CREB Binding Protein (CREBBP) (Ser262) antibodyCREBBP 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
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应用备注
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ELISA_Dilution: 1:10,000 - 1:50,000
Western_Blot_Dilution: 5 μg/mL
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说明
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Anti-CREBBP Antibody has been tested in ELISA and WB. Expect a band ~265kDa in western blot using appropriate tissue or lysates. Positive control used: Mouse brain, MOLT-4, A549, and PC3 lysates in Western Blots.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
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Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
Stabilizer: None
Preservative: 0.01 % (w/v) Sodium Azide -
储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store vial at -20° C or below prior to opening. This vial contains a relatively low volume of reagent (25 μL). To minimize loss of volume dilute 1:10 by adding 225 μL of the buffer stated above directly to the vial. Recap, mix thoroughly and briefly centrifuge to collect the volume at the bottom of the vial. Use this intermediate dilution when calculating final dilutions as recommended below. Store the vial at -20°C or below after dilution. Avoid cycles of freezing and thawing.
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有效期
- 12 months
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- CBP (CREBBP) (CREB Binding Protein (CREBBP))
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别名
- CREBBP
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背景
- Rabbit Anti-CREBBP Antibody, Rabbit Anti-CREB Binding Protein, CREB-Binding Protein, EC 2.3.1.48, CBP, Rubinstein-Taybi Syndrome, KAT3A, MKHK1, RSTS1, RSTS,CREBBP (CREB Binding Protein) is ubiquitously expressed. It acetylates histones, giving a specific tag for transcriptional activation and acetylates non-histone proteins, like NCOA3 and FOXO1. It binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes, so it's known to play critical roles in embryonic development, growth control, and homeostasis by coupling chromatin remodeling to transcription factor recognition. CREBBP acts as a coactivator of ALX1 and acts as a circadian transcriptional coactivator which enhances the activity of the circadian transcriptional activators: NPAS2-ARNTL/BMAL1 and CLOCK-ARNTL/BMAL1 heterodimers. It acetylates PCNA, in which this acetylation promotes removal of chromatin-bound PCNA and its degradation during nucleotide excision repair (NER). Functions as a transcriptional coactivator for SMAD4 in the TGF-beta signaling pathway. This protein shares regions of very high sequence similarity with protein p300 in its bromodomain, cysteine-histidine-rich regions, and histone acetyltransferase domain. Bromodomains (BRDs) are epigenetic reader domains that selectively recognize acetylated lysine residues on the tails of histone proteins and are the only known protein modules that can target acetylated lysine residues. Mutations in this gene cause Rubinstein-Taybi syndrome (RTS) and acute myeloid leukemia. Anti-CREBBP Antibody is useful for researchers interested in Transcription Factors, Histones, Epigenetics, and Cancer research.
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基因ID
- 1387
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UniProt
- Q92793
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途径
- TCR Signaling, Interferon-gamma Pathway, Stem Cell Maintenance, Chromatin Binding, Regulation of Lipid Metabolism by PPARalpha
抗原
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