TCF7 抗体 (AA 168-358)
Quick Overview for TCF7 抗体 (AA 168-358) (ABIN7539769)
抗原
See all TCF7 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 168-358
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原理
- TCF7 Antibody
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纯化方法
- Purified antibody
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免疫原
- Purified recombinant fragment of human TCF7 (AA: 168-358) expressed in E. Coli.
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亚型
- IgG1
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应用备注
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ELISA: 1/10000
FCM: 1/200 - 1/400
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限制
- 仅限研究用
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缓冲液
- Purified antibody in PBS with 0.05 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
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- TCF7 (Transcription Factor 7 (T-Cell Specific, HMG-Box) (TCF7))
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别名
- TCF7
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背景
- This gene encodes a member of the T-cell factor/lymphoid enhancer-binding factor family of high mobility group (HMG) box transcriptional activators. This gene is expressed predominantly in T-cells and plays a critical role in natural killer cell and innate lymphoid cell development. The encoded protein forms a complex with beta-catenin and activates transcription through a Wnt/beta-catenin signaling pathway. Mice with a knockout of this gene are viable and fertile, but display a block in T-lymphocyte differentiation. Alternative splicing results in multiple transcript variants. Naturally-occurring isoforms lacking the N-terminal beta-catenin interaction domain may act as dominant negative regulators of Wnt signaling.
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分子量
- 41.6 kDa
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基因ID
- 6932
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UniProt
- P36402
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途径
- WNT signaling
抗原
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