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Ephrin B2 抗体

EFNB2 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN7539249
发货至: 中国
  • 抗原 See all Ephrin B2 (EFNB2) 抗体
    Ephrin B2 (EFNB2)
    适用
    • 50
    • 33
    • 29
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    宿主
    • 46
    • 3
    • 1
    克隆类型
    • 40
    • 10
    多克隆
    标记
    • 29
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    This Ephrin B2 antibody is un-conjugated
    应用范围
    • 27
    • 16
    • 11
    • 8
    • 4
    • 2
    • 1
    • 1
    Western Blotting (WB)
    原理
    Ephrin-B2 antibody
    纯化方法
    Protein A purified
    免疫原
    recombinant human soluble Ephrin-B2
    Top Product
    Discover our top product EFNB2 Primary Antibody
  • 应用备注
    Western Blot: Use 1-5 μg/mL
    限制
    仅限研究用
  • 状态
    Lyophilized
    溶解方式
    Centrifuge vial prior to opening. Reconstitute in sterile water to a concentration of 0.1-1.0 mg/mL.
    缓冲液
    PBS
    储存条件
    4 °C,-20 °C
    储存方法
    The lyophilized antibody is stable for at least 2 years at -20°C. After sterile reconstitution the antibody is stable at 2-8°C for up to 6 months. Frozen aliquots are stable for at least 6 months when stored at -20°C. Addition of a carrier protein or 50% glycerol is recommended for frozen aliquots.
    有效期
    24 months
  • 抗原
    Ephrin B2 (EFNB2)
    别名
    Ephrin-B2 (EFNB2 产品)
    背景
    EPH-related receptor tyrosine kinase ligand 5, HTK ligand,The large families of Eph receptor tyrosine kinases and their Ephrin ligands transduce signals in a cell-cell contact-dependent fashion. They thereby coordinate the growth, differentiation, and patterning of almost every organ and tissue. Eph/Ephrin interactions can trigger a wide array of cellular responses, including cell adhesion, boundary formation, and repulsion. The exact mechanisms leading to this diversity of responses are unclear but appear to involve differential signaling, proteolytic cleavage of Ephrins, and endocytosis of the ligand-receptor complex. In the developing cardiovascular system, Eph and Ephrin molecules control the angiogenic remodeling of blood vessels and lymphatic vessels and play essential roles in endothelial cells as well as in supporting pericytes and vascular smooth muscle cells. Recent evidence suggests that Ephs and Ephrins may also be involved in pathological angiogenesis, in particular, the neovascularization of tumors. Consequently, the expression, interactions, or signaling of Eph/Ephrin molecules might be targets for future therapeutic approaches. Ephrins are naturally divided into two structural groups. All ligands share a conserved extracellular sequence, which most likely corresponds to the receptor-binding domain. This conserved sequence consists of approximately 125 amino acids and includes four invariant cysteines. The B-class ligands are transmembrane proteins, which can be tyrosine phosphorylated upon receptor ligation. Class B ephrins show 33 % amino acid sequence identity in their extracellular segments and 44 % amino acid sequence identity in their cytoplasmic regions.
    基因ID
    1948
    NCBI登录号
    NM_004093, NP_004084
    UniProt
    P52799
    途径
    RTK signaling, Regulation of Muscle Cell Differentiation
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