Insulin Receptor 抗体
Quick Overview for Insulin Receptor 抗体 (ABIN7538096)
抗原
See all Insulin Receptor (INSR) 抗体适用
宿主
克隆类型
标记
应用范围
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原理
- Rabbit polyclonal antibodies to Insulin Receptor
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特异性
- Insulin receptor
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交叉反应 (详细)
- May cross-react with other species
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纯化方法
- Immunogen affinity column
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免疫原
- Peptide conjugated to KLH (GGKKNGRILTLPRSNPS)
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亚型
- IgG, IgM
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应用备注
- Western blot: 0.1-1.0 μg/mL
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- Lot specific
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缓冲液
- Glycine pH 7.2
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储存条件
- 4 °C,-80 °C
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储存方法
- Short term up to 1 month at 2-8°C, long term can be held for up to five years at -70°C
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- Insulin Receptor (INSR)
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别名
- insulin receptor
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背景
- INSR is a receptor tyrosine kinase. Binding of insulin to the extracellular domain of INSR stimulates glucose uptake. INSR and IGF-1 receptors share major structural and functional similarity. The earliest cellular response to insulin stimulation is autophosphorylation of tyrosine in INSR. In humans, the INSR gene is located on chromosome 19. Defects in INSR are the cause of various insulin resistance syndromes and IGF-1R defects may also cause some forms of growth retardation.
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分子量
- 42226 Da
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基因ID
- 3643
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NCBI登录号
- NP_000199
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UniProt
- P06213
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途径
- NF-kappaB Signaling, RTK signaling, AMPK Signaling, Carbohydrate Homeostasis, Regulation of Cell Size, Regulation of Carbohydrate Metabolic Process, Growth Factor Binding, Negative Regulation of Transporter Activity
抗原
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