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Recombinant CCR5 抗体

This anti-CCR5 antibody is a 兔 单克隆 antibody detecting CCR5 in ELISA, FACS, Dep 和 SPR. Suitable for 人.
产品编号 ABIN7487682
发货至: 中国

Quick Overview for Recombinant CCR5 抗体 (ABIN7487682)

抗原

See all CCR5 抗体
CCR5 (Chemokine (C-C Motif) Receptor 5 (CCR5))

抗体类型

Recombinant Antibody

适用

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克隆类型

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单克隆

标记

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This CCR5 antibody is un-conjugated

应用范围

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ELISA, Flow Cytometry (FACS), Depletion (Dep), Surface Plasmon Resonance (SPR)

克隆位点

ST6
  • 原理

    Anti-CCR5 [ST6], Rabbit IgG, kappa

    特异性

    This antibody is specific for the YTSE region of the N-terminal extracellular domain of human CCR5.It also binds to rhesus CCR5.

    交叉反应

    猕猴

    产品特性

    Original Species of Ab: Rabbit

    Original Format of Ab: IgG

    纯化方法

    Protein A affinity purified

    免疫原

    This antibody was isolated from a phage displayed antibody fragment library. The library was generated from a New Zealand White rabbit immunised with purified CCR5-N-GST protein, and four rounds of panning were completed against immobilised CCR5-N-MBP antigen.

    亚型

    IgG kappa
  • 应用备注

    When expressed intracellularly, this antibody is able to inhibit the surface expression of human CCR5, conferring T-lymphocytes with immunity to CCR5-dependent HIV-1 infection (Steinberger et al, 2000). Humanised ST6 (ST6/34) also has the same depleting effect (Steinberger et al, 2000). The high affinity of this antibody for CCR5-N-MBP has been confirmed in surface plasmon resonance analysis (Steinberg et al, 2000). This antibody has been used to stain CCR5-expressing cells in flow cytometry, with no staining of control cells observed (Steinberger et al, 2000).

    限制

    仅限研究用
  • 浓度

    1 mg/mL

    缓冲液

    PBS with 0.02 % Proclin 300.

    储存液

    ProClin

    注意事项

    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    4 °C,-20 °C

    储存方法

    Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.
  • 抗原

    CCR5 (Chemokine (C-C Motif) Receptor 5 (CCR5))

    别名

    CCR5

    背景

    CD195, C-C chemokine receptor type 5, C-C CKR-5, CC-CKR-5, CCR-5, CHEMR13, HIV-1 fusion coreceptor, B8LFP0

    UniProt

    P51681

    途径

    Cellular Response to Molecule of Bacterial Origin, cAMP Metabolic Process, Regulation of Cell Size
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