MBD4 抗体
Quick Overview for MBD4 抗体 (ABIN7469292)
抗原
See all MBD4 抗体适用
宿主
克隆类型
标记
应用范围
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交叉反应
- 人
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纯化方法
- Purified by antigen-affinity chromatography.
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免疫原
- Recombinant protein encompassing a sequence within the center region of human MBD4. The exact sequence is proprietary.
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亚型
- IgG
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anti-Methyl-CpG Binding Domain Protein 4 (MBD4) (AA 323-351) antibody
MBD4 适用: 人 WB 宿主: 兔 Polyclonal RB40399 unconjugated
anti-Methyl-CpG Binding Domain Protein 4 (MBD4) (AA 566-580), (C-Term) antibodyMBD4 适用: 人, 小鼠, 大鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-Methyl-CpG Binding Domain Protein 4 (MBD4) (Middle Region) antibodyMBD4 适用: 人, 豚鼠 WB, ChIP 宿主: 兔 Polyclonal unconjugated
anti-Methyl-CpG Binding Domain Protein 4 (MBD4) (C-Term) antibodyMBD4 适用: 人, 小鼠, 大鼠 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB: 1:1000-1:10000. ICC/IF: 1:100-1:1000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.
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说明
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Positive Control: 3xFlag-human MBD4-transfected 293T cells
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- 1XPBS ( pH 7), 20 % Glycerol, 0.025 % ProClin 300
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
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- MBD4 (Methyl-CpG Binding Domain Protein 4 (MBD4))
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别名
- MBD4
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背景
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Synonyms: methyl-CpG binding domain 4, DNA glycosylase , MED1
Background: DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MBD4 may function to mediate the biological consequences of the methylation signal. In addition, MBD4 has protein sequence similarity to bacterial DNA repair enzymes and thus may have some function in DNA repair. Further, MBD4 gene mutations are detected in tumors with primary microsatellite-instability (MSI), a form of genomic instability associated with defective DNA mismatch repair, and MBD4 gene meets 4 of 5 criteria of a bona fide MIS target gene. [provided by RefSeq]
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分子量
- 66 kDa
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基因ID
- 8930
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UniProt
- O95243
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途径
- DNA Damage Repair
抗原
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