PAK3 抗体
Quick Overview for PAK3 抗体 (ABIN7468705)
抗原
See all PAK3 抗体适用
宿主
克隆类型
标记
应用范围
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交叉反应
 - 人, 小鼠, 大鼠
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纯化方法
 - Purified by antigen-affinity chromatography.
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免疫原
 - Recombinant protein encompassing a sequence within the center region of human PAK3. The exact sequence is proprietary.
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亚型
 - IgG
 
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应用备注
 - WB: 1:500-1:3000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.
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说明
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Positive Control: NIH-3T3 , BCL-1 , IMR32 , mouse brain , rat brain
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限制
 - 仅限研究用
 
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状态
 - Liquid
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浓度
 - 0.74 mg/mL
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缓冲液
 - 1XPBS ( pH 7), 1 % BSA, 20 % Glycerol, 0.01 % Thimerosal
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储存液
 - Thimerosal (Merthiolate)
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注意事项
 - This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
 - 4 °C,-20 °C
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储存方法
 - Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
 
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- PAK3
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别名
 - p21 (RAC1) activated kinase 3
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背景
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Synonyms: p21 (RAC1) activated kinase 3 , ARA , MRX30 , MRX47 , OPHN3 , PAK-3 , PAK3beta , bPAK , beta-PAK
Background: PAK proteins are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. PAK proteins, a family of serine/threonine p21-activating kinases, serve as targets for the small GTP binding proteins Cdc42 and RAC and have been implicated in a wide range of biological activities. The protein encoded by this gene forms an activated complex with GTP-bound RAS-like (P21), CDC2 and RAC1 proteins which then catalyzes a variety of targets. This protein may be necessary for dendritic development and for the rapid cytoskeletal reorganization in dendritic spines associated with synaptic plasticity. Defects in this gene are the cause of non-syndromic mental retardation X-linked type 30 (MRX30), also called X-linked mental retardation type 47 (MRX47). Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq]
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分子量
 - 62 kDa
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基因ID
 - 5063
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UniProt
 - O75914
 
抗原
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