PAK4 抗体
Quick Overview for PAK4 抗体 (ABIN7468702)
抗原
See all PAK4 抗体适用
宿主
克隆类型
标记
应用范围
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交叉反应
 - 人, 小鼠
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纯化方法
 - Purified by antigen-affinity chromatography.
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免疫原
 - Recombinant protein encompassing a sequence within the center region of human PAK4. The exact sequence is proprietary.
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亚型
 - IgG
 
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应用备注
 - WB: 1:500-1:3000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.
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说明
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Validation: Orthogonal
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限制
 - 仅限研究用
 
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状态
 - Liquid
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浓度
 - 1 mg/mL
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缓冲液
 - 1XPBS ( pH 7), 1 % BSA, 20 % Glycerol, 0.01 % Thimerosal
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储存液
 - Thimerosal (Merthiolate)
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注意事项
 - This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
 - 4 °C,-20 °C
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储存方法
 - Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
 
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- PAK4 (P21-Activated Kinase 4 (PAK4))
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别名
 - p21 (RAC1) activated kinase 4
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背景
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Synonyms: p21 (RAC1) activated kinase 4
Background: PAK proteins, a family of serine/threonine p21-activating kinases, include PAK1, PAK2, PAK3 and PAK4. PAK proteins are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. They serve as targets for the small GTP binding proteins Cdc42 and Rac and have been implicated in a wide range of biological activities. PAK4 interacts specifically with the GTP-bound form of Cdc42Hs and weakly activates the JNK family of MAP kinases. PAK4 is a mediator of filopodia formation and may play a role in the reorganization of the actin cytoskeleton. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq]
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分子量
 - 64 kDa
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基因ID
 - 10298
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UniProt
 - O96013
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途径
 - RTK signaling
 
抗原
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