IFT57 抗体
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- 抗原 See all IFT57 抗体
- IFT57 (Intraflagellar Transport 57 Homolog (IFT57))
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This IFT57 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- 交叉反应
- 人
- 纯化方法
- Purified by antigen-affinity chromatography.
- 免疫原
- Recombinant protein encompassing a sequence within the center region of human HIPPI. The exact sequence is proprietary.
- 亚型
- IgG
- Top Product
- Discover our top product IFT57 Primary Antibody
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- 应用备注
- WB: 1:500-1:3000. IHC-P: 1:100-1:1000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.
- 说明
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Positive Control: H1299
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 0.52 mg/mL
- 缓冲液
- 0.1M Tris-Glycine ( pH 7), 10 % Glycerol, 0.01 % Thimerosal
- 储存液
- Thimerosal (Merthiolate)
- 注意事项
- This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C,-20 °C
- 储存方法
- Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
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- 抗原
- IFT57 (Intraflagellar Transport 57 Homolog (IFT57))
- 别名
- intraflagellar transport 57 (IFT57 产品)
- 背景
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Synonyms: intraflagellar transport 57 , ESRRBL1 , HIPPI , MHS4R2 , OFD18
Background: Required for the formation of cilia. Plays an indirect role in sonic hedgehog signaling, cilia being required for all activity of the hedgehog pathway (By similarity). Has pro-apoptotic function via its interaction with HIP1, leading to recruit caspase-8 (CASP8) and trigger apoptosis. Has the ability to bind DNA sequence motif 5'-AAAGACATG-3' present in the promoter of caspase genes such as CASP1, CASP8 and CASP10, suggesting that it may act as a transcription regulator, however the relevance of such function remains unclear.
- 分子量
- 49 kDa
- 基因ID
- 55081
- UniProt
- Q9NWB7
- 途径
- Hedgehog Signaling, Positive Regulation of Endopeptidase Activity
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