Estrogen Receptor alpha 抗体 (AA 1-190)
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Quick Overview for Estrogen Receptor alpha 抗体 (AA 1-190) (ABIN7464705)
抗原
See all Estrogen Receptor alpha (ESR1) 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 1-190
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特异性
- This antibody is specific for ER alpha protein, and it does not cross react with ER beta protein.
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交叉反应
- 人, 兔
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纯化方法
- Protein G purified
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免疫原
- The region encoding amino acids 1-190 expressed in E. coli.
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亚型
- IgG1
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应用备注
- WB: 1:500-1:3000. IP: 1 - 5 μg/mL. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.
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说明
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Positive Control: MCF-7 , DDDDK-tagged ESR1-transfected 293T
Validation: Comparison, Orthogonal, Overexpression
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1.56 mg/mL
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缓冲液
- PBS, No Preservative
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储存液
- Without preservative
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储存条件
- 4 °C,-20 °C
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储存方法
- Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
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- Estrogen Receptor alpha (ESR1) (Estrogen Receptor 1 (ESR1))
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别名
- estrogen receptor 1
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背景
- Estrogen receptor 1 , ER , ESR , ESRA , ESTRR , Era , NR3A1,This gene encodes an estrogen receptor, a ligand-activated transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription. The protein localizes to the nucleus where it may form a homodimer or a heterodimer with estrogen receptor 2. Estrogen and its receptors are essential for sexual development and reproductive function, but also play a role in other tissues such as bone. Estrogen receptors are also involved in pathological processes including breast cancer, endometrial cancer, and osteoporosis. Alternative promoter usage and alternative splicing result in dozens of transcript variants, but the full-length nature of many of these variants has not been determined. [provided by RefSeq, Mar 2014]
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分子量
- 66 kDa
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基因ID
- 2099
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UniProt
- P03372
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途径
- Nuclear Receptor Transcription Pathway, EGFR Signaling Pathway, Retinoic Acid Receptor Signaling Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Steroid Hormone Mediated Signaling Pathway, Ribonucleoprotein Complex Subunit Organization, Ribosome Assembly
抗原
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