CSF1R 抗体
Quick Overview for CSF1R 抗体 (ABIN7457933)
抗原
See all CSF1R 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
-
-
纯化方法
- Purified
-
过滤
- 0.2 μm filtered
-
内毒素水平
- Low Endotoxin: Endotoxin level is < 2 EU/mg as Determined by LAL gel clotting assay.
-
亚型
- IgG2a, kappa
-
-
-
-
应用备注
- Optimal working dilution should be determined by the investigator.
-
说明
-
Matching Isotype Control: AF/LE Purified Rat IgG2a, κ Isotype Control (ABIN7469836)
-
限制
- 仅限研究用
-
-
-
浓度
- 0.5 mg/mL
-
缓冲液
- PBS, pH 7.2. Azide Free (AF)/Low Endotoxin (LE)
-
储存液
- Azide free
-
储存条件
- 4 °C
-
储存方法
- Store at 2~8°C. Do not freeze.
-
-
- CSF1R (Colony Stimulating Factor 1 Receptor (CSF1R))
-
别名
- CD115
-
背景
- Macrophage colony-stimulating factor 1 receptor,CSF-1 receptor (EC:2.7.10.1),CSF-1-R,CSF-1R,M-CSF-R,Proto-oncogene c-Fms,CD115,Csf1r,Csfmr,Fms,CSF-1R, also known as CD115 and M-CSFR, is a single-pass type I membrane protein and member of the platelet-derived growth factor receptor family. This c-fms (Fms proto-oncogene) gene product's natural ligands include M-CSF and IL-34. Structural studies of CD115 have described an Ig-like extracellular domain, a transmembrane domain, an intracellular juxtamembrane domain, a split tyrosine kinase domain, and a C-terminal tail receptor. Receptor activation induces homodimerization in addition to phosphorylation and ubiquitination of intracellular residues. CD115 directly influences tissue macrophage and osteoclast differentiation and proliferation. It is expressed on monocytes/macrophages, peritoneal exudate cells, plasmacytoid and conventional dendritic cells, and osteoclasts.
-
基因ID
- 12978
-
UniProt
- P09581
-
途径
- RTK signaling, Inositol Metabolic Process, Cell-Cell Junction Organization
抗原
-