CD40 抗体
Quick Overview for CD40 抗体 (ABIN7457872)
抗原
See all CD40 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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纯化方法
- Purified
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过滤
- 0.2 μm filtered
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内毒素水平
- Low Endotoxin: Endotoxin level is < 2 EU/mg as Determined by LAL gel clotting assay.
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亚型
- IgG2a, kappa
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应用备注
- Optimal working dilution should be determined by the investigator.
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说明
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Matching Isotype Control: AF/LE Purified Rat IgG2a, κ Isotype Control (ABIN7469836)
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限制
- 仅限研究用
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浓度
- 0.5 mg/mL
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缓冲液
- PBS, pH 7.2. Azide Free (AF)/Low Endotoxin (LE)
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储存液
- Azide free
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储存条件
- 4 °C
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储存方法
- Store at 2~8°C. Do not freeze.
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- CD40
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别名
- CD40
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背景
- Tumor necrosis factor receptor superfamily member 5,Cd40,B-cell surface antigen CD40,Bp50,CD40L receptor,CD40,Tnfrsf5,CD40 is a 48 kD type I transmembrane glycoprotein also known as Bp50. It is a member of the tumor necrosis factor receptor (TNFR) superfamily and is expressed on B cells, basal epithelial cells, macrophages, follicular dendritic cells, endothelial cells, and a subset of CD34+ hematopoietic progenitors. CD40 regulates B cell development/maturation, Ig isotype switching and, in combination with other signals such as IL-4, protects B cells from surface Ig-induced apoptosis and promotes proliferation. Interaction of CD40 with its ligand CD154 (gp39), which is expressed on activated T cells, is important in costimulation and immune regulation.
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基因ID
- 21939
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UniProt
- P27512
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途径
- NF-kappaB Signaling, Cellular Response to Molecule of Bacterial Origin, M Phase, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Cancer Immune Checkpoints
抗原
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