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beta Arrestin 1 抗体 (AA 368-418)

This anti-beta Arrestin 1 antibody is a 兔 多克隆 antibody detecting beta Arrestin 1 in WB, IP 和 IHC (fp). Suitable for 人.
产品编号 ABIN7454956
发货至: 中国

Quick Overview for beta Arrestin 1 抗体 (AA 368-418) (ABIN7454956)

抗原

See all beta Arrestin 1 (ARRB1) 抗体
beta Arrestin 1 (ARRB1) (Arrestin, beta 1 (ARRB1))

适用

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宿主

  • 89
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克隆类型

  • 80
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多克隆

标记

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This beta Arrestin 1 antibody is un-conjugated

应用范围

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Western Blotting (WB), Immunoprecipitation (IP), Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections) (IHC (fp))
  • 抗原表位

    • 20
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    AA 368-418

    原理

    Rabbit anti-Beta-Arrestin 1 Antibody, Affinity Purified

    纯化方法

    Affinity Purified

    免疫原

    Between AA 368 and 418

    亚型

    IgG
  • 应用备注

    IHC: 1:500 - 1:2,000. Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.

    IP: 2 - 10 μg/mg lysate

    WB: 1:2,000 - 1:10,000

    限制

    仅限研究用
  • 浓度

    1000 μg/mL

    缓冲液

    Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    4 °C

    有效期

    12 months
  • 抗原

    beta Arrestin 1 (ARRB1) (Arrestin, beta 1 (ARRB1))

    别名

    Beta-Arrestin 1

    背景

    Background: Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. Beta-arrestin 1 is a cytosolic protein and acts as a cofactor in the beta-adrenergic receptor kinase (BARK) mediated desensitization of beta-adrenergic receptors. Besides the central nervous system, it is expressed at high levels in peripheral blood leukocytes, and thus the BARK/beta-arrestin system is believed to play a major role in regulating receptor-mediated immune functions [taken from NCBI Entrez Gene (Gene ID: 408)].

    基因ID

    408

    NCBI登录号

    NP_004032

    UniProt

    P49407

    途径

    Positive Regulation of Peptide Hormone Secretion, Nuclear Hormone Receptor Binding, cAMP Metabolic Process, Myometrial Relaxation and Contraction, Synaptic Membrane, Regulation of G-Protein Coupled Receptor Protein Signaling, Phototransduction
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