beta Arrestin 1 抗体 (AA 368-418)
Quick Overview for beta Arrestin 1 抗体 (AA 368-418) (ABIN7454956)
抗原
See all beta Arrestin 1 (ARRB1) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 368-418
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原理
- Rabbit anti-Beta-Arrestin 1 Antibody, Affinity Purified
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纯化方法
- Affinity Purified
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免疫原
- Between AA 368 and 418
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亚型
- IgG
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应用备注
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IHC: 1:500 - 1:2,000. Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.
IP: 2 - 10 μg/mg lysate
WB: 1:2,000 - 1:10,000
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限制
- 仅限研究用
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浓度
- 1000 μg/mL
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缓冲液
- Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C
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有效期
- 12 months
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- beta Arrestin 1 (ARRB1) (Arrestin, beta 1 (ARRB1))
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别名
- Beta-Arrestin 1
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背景
- Background: Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. Beta-arrestin 1 is a cytosolic protein and acts as a cofactor in the beta-adrenergic receptor kinase (BARK) mediated desensitization of beta-adrenergic receptors. Besides the central nervous system, it is expressed at high levels in peripheral blood leukocytes, and thus the BARK/beta-arrestin system is believed to play a major role in regulating receptor-mediated immune functions [taken from NCBI Entrez Gene (Gene ID: 408)].
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基因ID
- 408
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NCBI登录号
- NP_004032
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UniProt
- P49407
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途径
- Positive Regulation of Peptide Hormone Secretion, Nuclear Hormone Receptor Binding, cAMP Metabolic Process, Myometrial Relaxation and Contraction, Synaptic Membrane, Regulation of G-Protein Coupled Receptor Protein Signaling, Phototransduction
抗原
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