COBRA1 抗体 (AA 530-580)
Quick Overview for COBRA1 抗体 (AA 530-580) (ABIN7454796)
抗原
See all COBRA1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 530-580
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原理
- Rabbit anti-COBRA1 Antibody, Affinity Purified
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纯化方法
- Affinity Purified
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免疫原
- between AA 530 and 580
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亚型
- IgG
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anti-Cofactor of BRCA1 (COBRA1) (Center) antibody
COBRA1 适用: 人, 小鼠 WB, IF, IHC (p), ICC 宿主: 兔 Polyclonal unconjugated
anti-Cofactor of BRCA1 (COBRA1) (AA 8-199) antibodyCOBRA1 适用: 人 WB, ELISA, IHC, ChIP 宿主: 兔 Polyclonal unconjugated
anti-Cofactor of BRCA1 (COBRA1) (AA 1-475) antibodyCOBRA1 适用: 人 WB, IF, IHC (p) 宿主: 小鼠 Polyclonal unconjugated
anti-Cofactor of BRCA1 (COBRA1) (AA 1-475) antibodyCOBRA1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Cofactor of BRCA1 (COBRA1) antibodyCOBRA1 适用: 人, 小鼠, 大鼠 WB 宿主: 小鼠 Monoclonal F7E4 unconjugated
anti-Cofactor of BRCA1 (COBRA1) antibodyCOBRA1 适用: 人 WB 宿主: 小鼠 Monoclonal F7E4 unconjugated
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应用备注
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IHC: 1:200 - 1:500. Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.
IP: 2 - 5 μg/mg lysate
WB: 1:2,000 - 1:10,000
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限制
- 仅限研究用
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浓度
- 200 μg/mL
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缓冲液
- Tris-buffered Saline containing 0.1 % BSA and 0.09 % Sodium Azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C
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有效期
- 12 months
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- COBRA1 (Cofactor of BRCA1 (COBRA1))
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别名
- COBRA1
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背景
- Background: COBRA1 (Cofactor of BRCA1) is also known as NELFB (negative elongation factor E). NELFB is one of four subunits that make up the NELF transcription elongation factor. The four subunits of NELF are NELF A (WHSC2), NELFB, either NELFC or NELFD, and NELFE. NELF, along with DRB sensitivity-inducing factor (DSIF), functions to cause transcriptional pausing of RNA polymerase II. COBRA1 was originally identified in a yeast two-hybrid screen of a human ovary cDNA library using the BRCA COOH terminus repeat, BRCT1, as the bait protein. In this study, COBRA1 was found to be involved in BRCT1-mediated chromatin remodeling. COBRA1 has also been found to interact with several nuclear receptors such as ERalpha and androgen receptor to modulate their transcriptional activity.
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基因ID
- 25920
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NCBI登录号
- NP_056271
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UniProt
- Q8WX92
抗原
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