CDC20 抗体 (AA 449-499)
Quick Overview for CDC20 抗体 (AA 449-499) (ABIN7454724)
抗原
See all CDC20 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 449-499
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原理
- Rabbit anti-CDC20 Antibody, Affinity Purified
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预测反应
- Pig
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纯化方法
- Affinity Purified
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免疫原
- between AA 449 and 499
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亚型
- IgG
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应用备注
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IHC: 1:500 - 1:2,000. Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.
IP: 2 - 10 μg/mg lysate
WB: 1:2,000 - 1:10,000
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限制
- 仅限研究用
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浓度
- 200 μg/mL
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缓冲液
- Tris-buffered Saline containing 0.1 % BSA and 0.09 % Sodium Azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C
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有效期
- 12 months
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- CDC20 (Cell Division Cycle 20 Homolog (S. Cerevisiae) (CDC20))
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别名
- CDC20
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背景
- Background: CDC20 is a WD repeat containing cell cycle-regulator that binds to and activates the ubiquitin-ligase activity of the APC/c (anaphase-promoting complex/cyclosome). APC/c ubiquitinating activity is responsible for the degradation of securin and cyclin B that prompts the onset of anaphase and exit from mitosis. CDC20 has also been reported to form a complex with histone deacetylases and can function as a transcriptional repressor involved in cell cycle arrest. As a regulator of APC/c activity, CDC20 plays a key role in the spindle-assembly checkpoint.
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基因ID
- 991
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NCBI登录号
- NP_001246
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UniProt
- Q12834
抗原
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