MCM5 抗体 (AA 1-50)
Quick Overview for MCM5 抗体 (AA 1-50) (ABIN7454594)
抗原
See all MCM5 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 1-50
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原理
- Rabbit anti-MCM5 Antibody, Affinity Purified
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纯化方法
- Affinity Purified
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免疫原
- between AA 1 and 50
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亚型
- IgG
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应用备注
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IHC: 1:500 - 1:2,000. Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.
IP: 2 - 4 μg/mg lysate. This antibody is efficient at pulling down the MCM2-7 complex.
WB: 1:5,000 - 1:20,000
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限制
- 仅限研究用
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浓度
- 1000 μg/mL
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缓冲液
- Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C
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有效期
- 12 months
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- MCM5 (Minichromosome Maintenance Complex Component 5 (MCM5))
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别名
- MCM5
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背景
- Background: The MCM (Mini-Chromosome Maintenance) complex is a key component of the pre-replication complex involved in replication licensing which restricts DNA replication to only once per cell cycle. The MCM complex is a heterohexamer of MCM2, MCM3, MCM4, MCM5, MCM6, and MCM7. MCM5 can form a subcomplex with MCM3. MCM5 also appears to play a role in transcription. MCM5 has been shown to interact with the signal transducer and activator of transcription 1 (STAT1) and demonstrated to be essential for STAT1 target gene transcription.
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基因ID
- 4174
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NCBI登录号
- NP_006730
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UniProt
- P33992
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途径
- DNA Damage Repair, Mitotic G1-G1/S Phases, DNA Replication, Chromatin Binding, Synthesis of DNA
抗原
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