Recombinant EPAS1 抗体 (AA 400-450)
Our Local Distributor
北京 101111
Quick Overview for Recombinant EPAS1 抗体 (AA 400-450) (ABIN7454018)
抗原
See all EPAS1 抗体抗体类型
适用
宿主
克隆类型
标记
应用范围
克隆位点
-
-
抗原表位
- AA 400-450
-
原理
- Rabbit anti-HIF2-alpha Recombinant Monoclonal Antibody [BL-95-1A2] - BSA-Free
-
纯化方法
- Purified
-
免疫原
- between AA 400 and 450
-
亚型
- IgG
-
-
-
-
应用备注
- Optimal working dilution should be determined by the investigator.
-
限制
- 仅限研究用
-
-
-
状态
- Liquid
-
浓度
- 1000 μg/mL
-
缓冲液
- Borate Buffered Saline (BBS) pH 8.2 with 0.09 % Sodium Azide, BSA-Free
-
储存液
- Sodium azide
-
注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
储存条件
- 4 °C
-
储存方法
- 2 - 8 °C
-
有效期
- 12 months
-
-
- EPAS1 (Endothelial PAS Domain Protein 1 (EPAS1))
-
别名
- HIF2-alpha
-
背景
- The gene EPAS1 encodes for the transcription factor endothelial PAS domain-containing protein 1, and is induced as oxygen levels fall. Commonly called hypoxia inducible factor 2A (HIF2a), this protein is involved in the induction of oxygen regulated genes, binding to core DNA sequence 5'-[AG]CGTG-3' within the hypoxia response element (HRE) of target gene promoters. An important cancer biomarker, HIF2a may also play a role in Tibetan high-altitude adaptation (Am J Hum Genet. 2015 Jul 2, 97(1): 54-66.) and mutations in the EPAS1 gene are associated with erythrocytosis familial type 4 [taken from NCBI Entrez Gene (Gene ID: 2034) and UniProtKB (Entry: Q99814)].
-
基因ID
- 2034
-
UniProt
- Q99814
-
途径
- Signaling Events mediated by VEGFR1 and VEGFR2, Warburg Effect
抗原
-