Recombinant TIM3 抗体 (AA 231-281)
Quick Overview for Recombinant TIM3 抗体 (AA 231-281) (ABIN7452586)
抗原
See all TIM3 (TIM 3) 抗体抗体类型
适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 231-281
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原理
- Rabbit anti-TIM3 Recombinant Monoclonal Antibody [BLR207K]
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免疫原
- between AA 231 and 281 (C-term)
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亚型
- IgG
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应用备注
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IP: 20 μL/1 mg lysate
WB: 01:01,00
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限制
- 仅限研究用
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浓度
- 100 μg/mL
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缓冲液
- Borate Buffered Saline (BBS) pH 8.2 with 0.1 % BSA and 0.09 % Sodium Azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C
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有效期
- 12 months
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- TIM3 (TIM 3) (Hepatitis A Virus Cellular Receptor 2 (TIM 3))
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别名
- TIM3
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物质类
- Virus
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背景
- Background: TIM3 (HAVCR2) is a cell surface receptor implicated in modulating innate and adaptive immune responses. It is generally accepted to have an inhibiting function. Reports on stimulating functions suggest that the activity may be influenced by the cellular context and/or the respective ligand. TIM3 regulates macrophage activation, inhibits T-helper type 1 lymphocyte (Th1)-mediated auto- and alloimmune responses, and promotes immunological tolerance. In CD8+ cells TIM3 attenuates TCR-induced signaling, specifically by blocking NF-kappaB and NFAT promoter activities resulting in the loss of IL-2 secretion. [taken from the Universal Protein Resource (UniProt) Q8TDQ0].
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基因ID
- 171285
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NCBI登录号
- NP_599011
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UniProt
- Q8VIM0
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途径
- Regulation of Lipid Metabolism by PPARalpha, Cancer Immune Checkpoints
抗原
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