Recombinant EPH Receptor A2 抗体 (AA 25-534)
Quick Overview for Recombinant EPH Receptor A2 抗体 (AA 25-534) (ABIN7452579)
抗原
See all EPH Receptor A2 (EPHA2) 抗体抗体类型
适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 25-534
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原理
- Rabbit anti-EphA2 Recombinant Monoclonal Antibody [BLR136H]
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免疫原
- residues 25-534 (ECD)
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亚型
- IgG
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应用备注
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IP: 20 μL/1 mg lysate
WB: 01:01,00
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限制
- 仅限研究用
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浓度
- 40 μg/mL
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缓冲液
- Borate Buffered Saline (BBS) pH 8.2 with 0.1 % BSA and 0.09 % Sodium Azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C
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有效期
- 12 months
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- EPH Receptor A2 (EPHA2)
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别名
- EphA2
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背景
- Background: Ephrin type-A receptor 2 (EphA2) is a member of the Eph family of tyrosine kinase receptors. Eph receptors have been shown to play a critical role in the development of the nervous system, where they regulate patterning during neural development. The ligands for Eph receptors are ephrins. Ephrin receptors and ligands have been found to be frequently overexpressed in a wide variety of cancers. Contrary to the usual finding that the oncogenic properties of tyrosine kinase receptors are promoted by the autophosphorylation of the receptor, it is the dephosphorylation of EphA2 that is associated with its oncogenic activity. The major study of EphA2 has been in relation to its contribution to malignancy and the possibility of targeting it in cancer therapy.
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基因ID
- 1969
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NCBI登录号
- NP_004422
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UniProt
- P29317
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途径
- RTK signaling
抗原
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