BRCA1 抗体 (pSer1280)
Quick Overview for BRCA1 抗体 (pSer1280) (ABIN7452574)
抗原
See all BRCA1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
 - pSer1280
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原理
 - Rabbit anti-Phospho BRCA1 (S1280) Antibody, Affinity Purified
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预测反应
 - Monkey,Chimpanzee
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纯化方法
 - Affinity Purified
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免疫原
 - surrounding serine 1280
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亚型
 - IgG
 
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应用备注
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IP: 2.5 μg/mg lysate
WB: 1:1,000 - 1:10,000
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限制
 - 仅限研究用
 
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浓度
 - 1000 μg/mL
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缓冲液
 - Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide
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储存液
 - Sodium azide
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注意事项
 - This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
 - 4 °C
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有效期
 - 12 months
 
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- BRCA1 (Breast Cancer 1 (BRCA1))
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别名
 - BRCA1
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背景
 - Background: BRCA1 was identified as a gene with germline mutations that predisposes women to breast and ovarian cancer. The BRCA1 tumor suppressor is a large protein that has been demonstrated to interact with a multitude of proteins involved in the DNA damage response and cell cycle checkpoints to maintain genomic integrity. BRCA1 functions by regulating the activities of its interacting proteins which mediate processes such as gene transcription, gene repression, protein phosphorylation, and ubiquitination.
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基因ID
 - 672
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NCBI登录号
 - NP_009225
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UniProt
 - P38398
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途径
 - Cell Division Cycle, DNA Damage Repair, Intracellular Steroid Hormone Receptor Signaling Pathway, Positive Regulation of Response to DNA Damage Stimulus
 
抗原
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