UPF3B 抗体 (AA 433-483)
Quick Overview for UPF3B 抗体 (AA 433-483) (ABIN7451537)
抗原
See all UPF3B 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 433-483
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原理
- Rabbit anti-UPF3B Antibody, Affinity Purified
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纯化方法
- Affinity Purified
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免疫原
- Between AA 433 and 483
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亚型
- IgG
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应用备注
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IP: 2 - 10 μg/mg lysate
WB: Not recommended
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限制
- 仅限研究用
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浓度
- 1000 μg/mL
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缓冲液
- Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C
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有效期
- 12 months
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- UPF3B (UPF3 Regulator of Nonsense Transcripts Homolog B (UPF3B))
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别名
- UPF3B
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背景
- Background: UPF3B (UPF regulator of nonsense transcripts homolog B) is involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by associating with the nuclear exon junction complex (EJC) and serving as link between the EJC core and NMD machinery. UPF3B recruits UPF2 at the cytoplasmic side of the nuclear envelope and the subsequent formation of an UPF1-UPF2-UPF3 surveillance complex (including UPF1 bound to release factors at the stalled ribosome) is believed to activate NMD. In cooperation with UPF2, UPF3B stimulates both ATPase and RNA helicase activities of UPF1 [taken from the Universal Protein Resource (UniProt) Q9BZI7].
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基因ID
- 65109
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NCBI登录号
- NP_542199
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UniProt
- Q9BZI7
抗原
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