UPF3B 抗体 (N-Term)
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北京 101111
Quick Overview for UPF3B 抗体 (N-Term) (ABIN2776563)
抗原
See all UPF3B 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- N-Term
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原理
- UPF3B Antibody - N-terminal region
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序列
- MKEEKEHRPK EKRVTLLTPA GATGSGGGTS GDSSKGEDKQ DRNKEKKEAL
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预测反应
- Cow: 100%, Dog: 100%, Human: 100%, Mouse: 93%, Pig: 93%, Rabbit: 93%, Rat: 100%
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产品特性
- This is a rabbit polyclonal antibody against UPF3B. It was validated on Western Blot and immunohistochemistry.
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纯化方法
- Protein A purified
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免疫原
- The immunogen is a synthetic peptide directed towards the N terminal region of human UPF3B
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anti-UPF3 Regulator of Nonsense Transcripts Homolog B (UPF3B) (C-Term) antibody
UPF3B 适用: 人, 小鼠, 大鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-UPF3 Regulator of Nonsense Transcripts Homolog B (UPF3B) (AA 319-423) antibodyUPF3B 适用: 人 IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-UPF3 Regulator of Nonsense Transcripts Homolog B (UPF3B) (N-Term) antibodyUPF3B 适用: 人, Cow WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-UPF3 Regulator of Nonsense Transcripts Homolog B (UPF3B) antibodyUPF3B 适用: 人, 犬 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-UPF3 Regulator of Nonsense Transcripts Homolog B (UPF3B) (AA 252-301) antibodyUPF3B 适用: 人, 犬, 兔, 猴 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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说明
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We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP40998-100UG
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1.0 mg/mL
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缓冲液
- Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- prevent freeze-thaw cycles
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储存条件
- 4 °C,-20 °C
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储存方法
- For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.
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: "RNA sequencing of synaptic and cytoplasmic Upf1-bound transcripts supports contribution of nonsense-mediated decay to epileptogenesis." in: Scientific reports, Vol. 7, pp. 41517, (2017) (PubMed).
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- UPF3B (UPF3 Regulator of Nonsense Transcripts Homolog B (UPF3B))
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别名
- UPF3B
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背景
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Background Information: UPF3B is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. The protein is one of two functional homologs to yeast Upf3p. This protein binds to the mRNA and remains bound after nuclear export, acting as a nucleocytoplasmic shuttling protein. It forms with Y14 a complex that binds specifically 20 nt upstream of exon-exon junctionsThis gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. The encoded protein is one of two functional homologs to yeast Upf3p. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein binds to the mRNA and remains bound after nuclear export, acting as a nucleocytoplasmic shuttling protein. It forms with Y14 a complex that binds specifically 20 nt upstream of exon-exon junctions. This gene is located on the long arm of chromosome X. Two splice variants encoding different isoforms have been found for this gene.
Gene Name: UPF3 regulator of nonsense transcripts homolog B (yeast)
Alternative Symbols: MRX62, MRX82, UPF3X, HUPF3B, MRXS14, RENT3B, UPF3BP1, UPF3BP2, UPF3BP3, Upf3p-X
Protein Name: Regulator of nonsense transcripts 3B
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分子量
- 52kDa
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基因ID
- 65109
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NCBI登录号
- NP_075386
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UniProt
- Q9BZI7
抗原
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