ERBB3 抗体 (AA 1275-1325)
Quick Overview for ERBB3 抗体 (AA 1275-1325) (ABIN7451238)
抗原
See all ERBB3 抗体适用
宿主
克隆类型
标记
应用范围
-
-
抗原表位
- AA 1275-1325
-
原理
- Rabbit anti-ErbB3 Antibody, Affinity Purified
-
预测反应
- Orangutan
-
纯化方法
- Affinity Purified
-
免疫原
- Between AA 1275 and 1325
-
亚型
- IgG
-
-
-
-
应用备注
-
IP: 2 - 10 μg/mg lysate
WB: Not recommended. Use rabbit anti-ErbB3 antibody ABIN7449726.
-
限制
- 仅限研究用
-
-
-
浓度
- 1000 μg/mL
-
缓冲液
- Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide
-
储存液
- Sodium azide
-
注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
储存条件
- 4 °C
-
有效期
- 12 months
-
-
- ERBB3 (Receptor Tyrosine-Protein Kinase ErbB-3 (ERBB3))
-
别名
- ErbB3
-
背景
- Background: ErbB3, also known as HER3, is a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers, including prostate, bladder, and breast tumors[taken from NCBI Entrez Gene (Gene ID: 2065)].
-
基因ID
- 2065
-
NCBI登录号
- NP_001973
-
UniProt
- P21860
-
途径
- RTK signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway
抗原
-