Caspase 4 抗体
Quick Overview for Caspase 4 抗体 (ABIN7384346)
抗原
See all Caspase 4 (CASP4) 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
-
-
纯化方法
- Affinity Purified
-
亚型
- IgG
-
-
anti-Caspase 4, Apoptosis-Related Cysteine Peptidase (CASP4) (AA 1-377) antibody
CASP4 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 7G7 unconjugated
anti-Caspase 4, Apoptosis-Related Cysteine Peptidase (CASP4) (AA 290-377) antibodyCASP4 适用: 人 WB, ELISA, ICC, IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Caspase 4, Apoptosis-Related Cysteine Peptidase (CASP4) (AA 82-226) antibodyCASP4 适用: 人 WB, IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Caspase 4, Apoptosis-Related Cysteine Peptidase (CASP4) antibodyCASP4 适用: 小鼠, 大鼠 WB, ELISA, IP, FACS 宿主: 大鼠 Monoclonal 8A5 unconjugated
anti-Caspase 4, Apoptosis-Related Cysteine Peptidase (CASP4) (Cleaved-Gln81) antibodyCASP4 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Caspase 4, Apoptosis-Related Cysteine Peptidase (CASP4) (AA 78-265) antibodyCASP4 适用: 人 WB, ELISA, ICC, IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Caspase 4, Apoptosis-Related Cysteine Peptidase (CASP4) (AA 81-270) antibodyCASP4 适用: Cow WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Caspase 4, Apoptosis-Related Cysteine Peptidase (CASP4) (Internal Region) antibodyVerified CASP4 适用: 人 WB, ELISA 宿主: 山羊 Polyclonal unconjugated
anti-Caspase 4, Apoptosis-Related Cysteine Peptidase (CASP4) (AA 111-194) antibodyCASP4 适用: 人 WB, IHC, ELISA, ICC, IF, FACS 宿主: 兔 Polyclonal unconjugated
anti-Caspase 4, Apoptosis-Related Cysteine Peptidase (CASP4) (AA 104-124) antibodyCASP4 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
-
-
应用备注
- WB 1:500-1:1000
-
限制
- 仅限研究用
-
-
-
浓度
- 300 μg/mL
-
缓冲液
- 50 mM Tris-Glycine( pH 7.4), 0.15M NaCl, 40 % Glycerol, 0.01 % Sodium azide and 0.05 % BSA
-
储存液
- Sodium azide
-
注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
储存条件
- -20 °C
-
储存方法
- Store at -20°C. Avoid freeze / thaw cycles.
-
-
- Caspase 4 (CASP4) (Caspase 4, Apoptosis-Related Cysteine Peptidase (CASP4))
-
别名
- Caspase 11
-
背景
- Caspl,ich-3,CASP-4,Casp11,CASP-11,Proinflammatory caspase (PubMed:8702803, PubMed:9038361, PubMed:25119034). Essential effector of NLRP3 inflammasome-dependent CASP1 activation and IL1B and IL18 secretion in response to non-canonical activators, such as UVB radiation, cholera enterotoxin subunit B and cytosolic LPS, as well as infection with Gram-negative bacteria (PubMed:22002608). Independently of NLRP3 inflammasome and CASP1, promotes pyroptosis, through GSDMD cleavage and activation, and IL1A, IL18 and HMGB1 release in response to non-canonical inflammasome activators (PubMed:22002608, PubMed:26320999, PubMed:26375003). Plays a crucial role in the restriction of Salmonella typhimurium replication in colonic epithelial cells during infection. In later stages of the infection (>3 days post infection), LPS from cytosolic Salmonella triggers CASP4 activation, which ultimately results in the pyroptosis of the infected cells and their extrusion into the gut lumen, as well as in IL18 secretion. Pyroptosis limits bacterial replication, while cytokine secretion promotes the recruitment and activation of immune cells and triggers mucosal inflammation (PubMed:25121752). Involved in LPS-induced IL6 secretion, this activity may not require caspase enzymatic activity . Involved in cell death induced by endoplasmic reticulum stress . Activated by direct binding to LPS without the need of an upstream sensor (PubMed:25119034). Does not directly process IL1B (PubMed:8702803, PubMed:9038361). During non-canonical inflammasome activation, cuts CGAS and may play a role in the regulation of antiviral innate immune activation (PubMed:28314590).
-
分子量
-
Observed_MW: 43/38kDa
Calculated_MW: 43kDa
-
基因ID
- 12363
-
UniProt
- P70343
-
途径
- Apoptosis, Caspase Cascade in Apoptosis, Positive Regulation of Endopeptidase Activity
抗原
-
