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CD40 Ligand 抗体

This anti-CD40 Ligand antibody is a 小鼠 单克隆 antibody detecting CD40 Ligand in FACS. Suitable for 人.
产品编号 ABIN7271841
发货至: 中国

Quick Overview for CD40 Ligand 抗体 (ABIN7271841)

抗原

See all CD40 Ligand (CD40LG) 抗体
CD40 Ligand (CD40LG)

适用

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宿主

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小鼠

克隆类型

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单克隆

标记

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This CD40 Ligand antibody is un-conjugated

应用范围

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Flow Cytometry (FACS)

质量等级

GMP Grade

克隆位点

5C8
  • 原理

    CD154 Unconjugated Antibody

    产品特性

    The clone 5C8, a mouse monoclonal antibody, specifically recognizes a ~30-33 kDa activation-induced human CD4+ T cells surface molecule known as CD154 or CD40 ligand (CD40L). The CD40 interacts with CD154 through T cell-B cell activating molecule, gp39, TNF cytokine related activation protein. CD154 is primarily expressed on the surface of activated CD4+ T cells but can also be expressed by platelets, mast cells, macrophages, basophils, NK cells, B cells, CD8+ T cells as well as non-hematopoietic cells including smooth muscle cells, endothelial cells, and epithelial cells. CD154 plays important roles in the pathogenesis of certain blood cancer such as the CD4+ T cells of patients with CLL fail to express surface CD154 antigen even after CD3 ligation, and proximal and distal activation events are required for the neonatal CD4+ T cells for the CD154 gene transcription to establish the normal immune system.

    纯化方法

    Purified

    纯度

    >95 %

    免疫原

    Human D1.1 T cell line

    亚型

    IgG2a, kappa
  • 应用备注

    Optimal working dilution should be determined by the investigator.

    限制

    仅限研究用
  • 状态

    Liquid

    缓冲液

    PBS pH 7.2, 0.1 % (w/v) BSA, 0.09 % (w/v) sodium azide

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    4 °C
  • 抗原

    CD40 Ligand (CD40LG)

    别名

    CD154

    基因ID

    595

    UniProt

    P29965

    途径

    NF-kappaB Signaling, Production of Molecular Mediator of Immune Response, Cancer Immune Checkpoints
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