Melanoma gp100 抗体 (AA 25-300)
Quick Overview for Melanoma gp100 抗体 (AA 25-300) (ABIN7269510)
抗原
See all Melanoma gp100 (PMEL) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 25-300
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原理
- PMEL Rabbit pAb
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序列
- KVPRNQDWLG VSRQLRTKAW NRQLYPEWTE AQRLDCWRGG QVSLKVSNDG PTLIGANASF SIALNFPGSQ KVLPDGQVIW VNNTIINGSQ VWGGQPVYPQ ETDDACIFPD GGPCPSGSWS QKRSFVYVWK TWGQYWQVLG GPVSGLSIGT GRAMLGTHTM EVTVYHRRGS RSYVPLAHSS SAFTITDQVP FSVSVSQLRA LDGGNKHFLR NQPLTFALQL HDPSGYLAEA DLSYTWDFGD SSGTLISRAL VVTHTYLEPG PVTAQVVLQA AIPLTS
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交叉反应
- 人, 小鼠, 大鼠
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产品特性
- Polyclonal Antibodies
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纯化方法
- Affinity purification
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免疫原
- Recombinant fusion protein containing a sequence corresponding to amino acids 25-300 of human PMEL (NP_008859.1).
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亚型
- IgG
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应用备注
- WB,1:500 - 1:2000,IF,1:50 - 1:200
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C. Avoid freeze / thaw cycles.
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- Melanoma gp100 (PMEL) (Premelanosome Protein (PMEL))
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别名
- PMEL
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背景
- This gene encodes a melanocyte-specific type I transmembrane glycoprotein. The encoded protein is enriched in melanosomes, which are the melanin-producing organelles in melanocytes, and plays an essential role in the structural organization of premelanosomes. This protein is involved in generating internal matrix fibers that define the transition from Stage I to Stage II melanosomes. This protein undergoes a complex pattern of prosttranslational processing and modification that is essential to the proper functioning of the protein. A secreted form of this protein that is released by proteolytic ectodomain shedding may be used as a melanoma-specific serum marker. Alternate splicing results in multiple transcript variants.,PMEL,D12S53E,ME20,ME20-M,ME20M,P1,P100,PMEL17,SI,SIL,SILV,gp100,Cancer,Tumor immunology,Tumor-associated antigens,Signal Transduction,Endocrine & Metabolism,Amino acid metabolism,Immunology & Inflammation,PMEL
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分子量
- 60kDa/66kDa/70kDa
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基因ID
- 6490
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UniProt
- P40967
抗原
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