MAP3K4 抗体 (AA 1-100)
Quick Overview for MAP3K4 抗体 (AA 1-100) (ABIN7268654)
抗原
See all MAP3K4 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 1-100
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原理
- MAP3K4 Rabbit pAb
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序列
- MREAAAALVP PPAFAVTPAA AMEEPPPPPP PPPPPPEPET ESEPECCLAA RQEGTLGDSA CKSPESDLED FSDETNTENL YGTSPPSTPR QMKRMSTKHQ
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交叉反应
- 人, 大鼠
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产品特性
- Polyclonal Antibodies
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纯化方法
- Affinity purification
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免疫原
- A synthetic peptide corresponding to a sequence within amino acids 1-100 of human MAP3K4 (NP_005913.2).
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亚型
- IgG
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anti-Mitogen-Activated Protein Kinase Kinase Kinase 4 (MAP3K4) (AA 1201-1300) antibody
MAP3K4 适用: 人 ELISA, WB, IHC (p) 宿主: 小鼠 Monoclonal 4F10 unconjugated
anti-Mitogen-Activated Protein Kinase Kinase Kinase 4 (MAP3K4) (AA 1201-1300) antibodyMAP3K4 适用: 人 ELISA, WB, PLA 宿主: 小鼠 Monoclonal 6A12 unconjugated
anti-Mitogen-Activated Protein Kinase Kinase Kinase 4 (MAP3K4) (AA 53-145) antibodyMAP3K4 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Mitogen-Activated Protein Kinase Kinase Kinase 4 (MAP3K4) (AA 1201-1300) antibodyMAP3K4 适用: 人 ELISA, WB 宿主: 小鼠 Monoclonal 5D4 unconjugated
anti-Mitogen-Activated Protein Kinase Kinase Kinase 4 (MAP3K4) (N-Term) antibodyMAP3K4 适用: 人, 小鼠 ELISA, IHC, WB 宿主: 兔 Polyclonal unconjugated
anti-Mitogen-Activated Protein Kinase Kinase Kinase 4 (MAP3K4) (C-Term) antibodyMAP3K4 适用: 人, 小鼠, 大鼠 IHC, WB 宿主: 兔 Polyclonal unconjugated
anti-Mitogen-Activated Protein Kinase Kinase Kinase 4 (MAP3K4) (AA 1065-1097), (Middle Region) antibodyMAP3K4 适用: 人 WB, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
anti-Mitogen-Activated Protein Kinase Kinase Kinase 4 (MAP3K4) (AA 1067-1097) antibodyMAP3K4 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB,1:500 - 1:2000,IHC,1:100 - 1:200
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C. Avoid freeze / thaw cycles.
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- MAP3K4 (Mitogen-Activated Protein Kinase Kinase Kinase 4 (MAP3K4))
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别名
- MAP3K4
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背景
- The central core of each mitogen-activated protein kinase (MAPK) pathway is a conserved cascade of 3 protein kinases: an activated MAPK kinase kinase (MAPKKK) phosphorylates and activates a specific MAPK kinase (MAPKK), which then activates a specific MAPK. While the ERK MAPKs are activated by mitogenic stimulation, the CSBP2 and JNK MAPKs are activated by environmental stresses such as osmotic shock, UV irradiation, wound stress, and inflammatory factors. This gene encodes a MAPKKK, the MEKK4 protein, also called MTK1. This protein contains a protein kinase catalytic domain at the C terminus. The N-terminal nonkinase domain may contain a regulatory domain. Expression of MEKK4 in mammalian cells activated the CSBP2 and JNK MAPK pathways, but not the ERK pathway. In vitro kinase studies indicated that recombinant MEKK4 can specifically phosphorylate and activate PRKMK6 and SERK1, MAPKKs that activate CSBP2 and JNK, respectively but cannot phosphorylate PRKMK1, an MAPKK that activates ERKs. MEKK4 is a major mediator of environmental stresses that activate the CSBP2 MAPK pathway, and a minor mediator of the JNK pathway. Several alternatively spliced transcripts encoding distinct isoforms have been described.,MAP3K4,MAPKKK4,MEKK 4,MEKK4,MTK1,PRO0412,Signal Transduction,Kinase,MAPK-JNK Signaling Pathway,MAPK-P38 Signaling Pathway,Cell Biology & Developmental Biology,Cytoskeleton,Actins,Immunology & Inflammation,B Cell Receptor Signaling Pathway,Neuroscience,MAP3K4
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分子量
- 177kDa/181kDa
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基因ID
- 4216
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UniProt
- Q9Y6R4
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途径
- MAPK Pathway
抗原
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