HCAR2 抗体 (AA 250-350)
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北京 101111
Quick Overview for HCAR2 抗体 (AA 250-350) (ABIN7267804)
抗原
See all HCAR2 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 250-350
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原理
- HCAR2 Rabbit pAb
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序列
- VRIRIFWLLH TSGTQNCEVY RSVDLAFFIT LSFTYMNSML DPVVYYFSSP SFPNFFSTLI NRCLQRKMTG EPDNNRSTSV ELTGDPNKTR GAPEALMANS G
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交叉反应
- 人, 小鼠, 大鼠
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产品特性
- Polyclonal Antibodies
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纯化方法
- Affinity purification
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免疫原
- A synthetic peptide corresponding to a sequence within amino acids 250-350 of human HCAR2 (NP_808219.1).
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亚型
- IgG
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anti-Hydroxycarboxylic Acid Receptor 2 (HCAR2) (AA 82-94), (Extracellular) antibody
HCAR2 适用: 小鼠 IHC, WB, FACS, LCI 宿主: 兔 Polyclonal unconjugated
anti-Hydroxycarboxylic Acid Receptor 2 (HCAR2) antibodyHCAR2 适用: 人, 小鼠, 大鼠 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Hydroxycarboxylic Acid Receptor 2 (HCAR2) (AA 82-94), (Extracellular) antibody (FITC)HCAR2 适用: 小鼠 FACS, LCI 宿主: 兔 Polyclonal FITC
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应用备注
- WB,1:500 - 1:2000,IHC,1:50 - 1:200,IF,1:50 - 1:200
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C. Avoid freeze / thaw cycles.
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- HCAR2 (Hydroxycarboxylic Acid Receptor 2 (HCAR2))
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别名
- HCAR2
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背景
- Acts as a high affinity receptor for both nicotinic acid (also known as niacin and (D-beta-hydroxybutyrate and mediates increased adiponectin secretion and decreased lipolysis through G(i-protein-mediated inhibition of adenylyl cyclase. This pharmacological effect requires nicotinic acid doses that are much higher than those provided by a normal diet. Mediates nicotinic acid-induced apoptosis in mature neutrophils. Receptor activation by nicotinic acid results in reduced cAMP levels which may affect activity of cAMP-dependent protein kinase A and phosphorylation of target proteins, leading to neutrophil apoptosis. The rank order of potency for the displacement of nicotinic acid binding is 5-methyl pyrazole-3-carboxylic acid = pyridine-3-acetic acid > acifran > 5-methyl nicotinic acid = acipimox >> nicotinuric acid = nicotinamide.,HCAR2,GPR109A,HCA2,HM74a,HM74b,NIACR1,PUMAG,Puma-g,Cancer,Tumor suppressors,p53 pathway,Signal Transduction,G protein signaling,G-Protein-Coupled Receptors(GPCR),Cell Biology & Developmental Biology,Apoptosis,Endocrine & Metabolism,Lipid Metabolism,Hydrolysis,Cardiovascular,Lipids,HCAR2
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分子量
- 42kDa
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基因ID
- 338442
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UniProt
- Q8TDS4
抗原
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