PERK 抗体 (pThr982)
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北京 101111
Quick Overview for PERK 抗体 (pThr982) (ABIN7267032)
抗原
See all PERK (EIF2AK3) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- pThr982
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原理
- Phospho-PERK-T982 Rabbit pAb
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交叉反应
- 人, 小鼠, 大鼠
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产品特性
- Phosphorylated Antibodies
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纯化方法
- Affinity purification
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免疫原
- A phospho specific peptide corresponding to residues surrounding T982 of human PERK.
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亚型
- IgG
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应用备注
- WB,1:500 - 1:2000
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C. Avoid freeze / thaw cycles.
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- PERK (EIF2AK3) (Eukaryotic Translation Initiation Factor 2-alpha Kinase 3 (EIF2AK3))
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别名
- EIF2AK3
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背景
- The protein encoded by this gene phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2, leading to its inactivation, and thus to a rapid reduction of translational initiation and repression of global protein synthesis. This protein is thought to modulate mitochondrial function. It is a type I membrane protein located in the endoplasmic reticulum (ER), where it is induced by ER stress caused by malfolded proteins. Mutations in this gene are associated with Wolcott-Rallison syndrome.,EIF2AK3,PEK,PERK,WRS,Epigenetics & Nuclear Signaling,Translation Control,Regulation of eIF2,Signal Transduction,Kinase,Serine/threonine kinases,Cell Biology & Developmental Biology,Apoptosis,Protein folding,Endocrine & Metabolism,Endocrine and metabolic diseases,Diabetes,Metabolic disorders,Obesity,Neuroscience,Neurodegenerative Diseases,Protein phosphorylation,EIF2AK3
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分子量
- 125kDa
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基因ID
- 9451
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UniProt
- Q9NZJ5
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途径
- Hormone Transport, ER-Nucleus Signaling, Positive Regulation of Endopeptidase Activity, Hepatitis C, Unfolded Protein Response
抗原
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